{"id":59558,"date":"2024-01-16T13:36:03","date_gmt":"1970-01-01T00:00:00","guid":{"rendered":"https:\/\/minipress.ru\/katalog\/?p=59558"},"modified":"2024-01-16T13:36:03","modified_gmt":"1970-01-01T00:00:00","slug":"binders-for-wet-granulation","status":"publish","type":"post","link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/pharmaceutical-production-technologies\/binders-for-wet-granulation\/","title":{"rendered":"Binders for wet granulation"},"content":{"rendered":"
[vc_row][vc_column][vc_column_text]<\/span>\n\nThere<\/span> are<\/span> some<\/span> requirements<\/span> for<\/span> the<\/span> granulating<\/span> liquid,<\/span> one<\/span> of<\/span> them<\/span> is<\/span> that<\/span> the<\/span> granulating<\/span> liquid<\/span> should<\/span> not<\/span> dissolve<\/span> the<\/span> active<\/span> substance.<\/span> Water,<\/span> an<\/span> aqueous<\/span> solution<\/span> of<\/span> ethanol,<\/span> acetone<\/span> and<\/span> methylene<\/span> chloride<\/span> can<\/span> be<\/span> used<\/span> as<\/span> a<\/span> granulating<\/span> liquid.<\/span> A<\/span> wide<\/span> range<\/span> of<\/span> substances<\/span> are<\/span> used<\/span> as<\/span> binding<\/span> agents<\/span> for<\/span> wet<\/span> granulation<\/span> in<\/span> modern<\/span> pharmaceutical<\/span> production,<\/span> for<\/span> example:<\/span> starch<\/span> (5-15%<\/span> g\/g),<\/span> starch<\/span> derivatives,<\/span> cellulose<\/span> derivatives<\/span> that<\/span> improve<\/span> the<\/span> plasticity<\/span> of<\/span> granules,<\/span> as<\/span> well<\/span> as<\/span> gelatin<\/span> (1-3%<\/span> g\/<\/span> g)<\/span> and<\/span> PVP<\/span> (3-10%<\/span> g\/<\/span> g).<\/span> The<\/span> most<\/span> common<\/span> and<\/span> effective<\/span> binder<\/span> for<\/span> wet<\/span> granulation<\/span> in<\/span> the<\/span> modern<\/span> pharmaceutical<\/span> industry<\/span> is<\/span> a<\/span> synthetic<\/span> polymer<\/span> such<\/span> as<\/span> Collidone<\/span> (PVP),<\/span> various<\/span> brands<\/span> of<\/span> which<\/span> (Collidone<\/span> 25,<\/span> 30<\/span> and<\/span> 90F)<\/span> are<\/span> widely<\/span> represented<\/span> on<\/span> the<\/span> market.<\/span>\n\n[\/vc_column_text][\/vc_column][\/vc_row]<\/span><\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][vc_column_text] There are some requirements for the granulating liquid, one of them is that the granulating liquid should not dissolve the active substance. Water, an aqueous solution of ethanol, acetone and methylene chloride can be used as a granulating liquid. A wide range of substances are used as binding agents for wet granulation in modern…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false,"two_page_speed":[]},"categories":[2232,2175],"tags":[2380,2381,2372,2376,2373,2378,2374,73,72,43,71,68,2239,64,2377,2370,2379,2190,39,67,2375,2192,2240,2371,66,65],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Author Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"GRANULATION PROCESS IN TABLET PRODUCTION<\/a> PHARMACEUTICAL PRODUCTION TECHNOLOGIES<\/a>","rttpg_excerpt":"[vc_row][vc_column][vc_column_text] There are some requirements for the granulating liquid, one of them is that the granulating liquid should not dissolve the active substance. Water, an aqueous solution of ethanol, acetone and methylene chloride can be used as a granulating liquid. A wide range of substances are used as binding agents for wet granulation in modern...","_links":{"self":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/59558"}],"collection":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/comments?post=59558"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/59558\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/media?parent=59558"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/categories?post=59558"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/tags?post=59558"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}