{"id":59550,"date":"2024-01-16T11:17:01","date_gmt":"1970-01-01T00:00:00","guid":{"rendered":"https:\/\/minipress.ru\/katalog\/?p=59550"},"modified":"2024-01-16T11:17:01","modified_gmt":"1970-01-01T00:00:00","slug":"wet-granulation-of-powders","status":"publish","type":"post","link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/pharmaceutical-production-technologies\/wet-granulation-of-powders\/","title":{"rendered":"Wet granulation of powders"},"content":{"rendered":"
[vc_row][vc_column][vc_column_text]<\/span>\n\nWet<\/span> granulation<\/span> is<\/span> subjected<\/span> to<\/span> powders<\/span> having<\/span> poor<\/span> flowability<\/span> and<\/span> insufficient<\/span> ability<\/span> to<\/span> bond<\/span> between<\/span> particles.<\/span> In<\/span> both<\/span> cases,<\/span> binding<\/span> solutions<\/span> are<\/span> added<\/span> to<\/span> the<\/span> mass,<\/span> improving<\/span> the<\/span> adhesion<\/span> between<\/span> the<\/span> particles.<\/span> Granulation,<\/span> or<\/span> wiping<\/span> of<\/span> the<\/span> wet<\/span> mass,<\/span> is<\/span> carried<\/span> out<\/span> in<\/span> order<\/span> to<\/span> compact<\/span> the<\/span> powder<\/span> and<\/span> obtain<\/span> uniform<\/span> grains<\/span> \u2014<\/span> granules<\/span> with<\/span> good<\/span> flowability.<\/span> Wet<\/span> granulation<\/span> includes<\/span> successive<\/span> stages:<\/span> grinding<\/span> of<\/span> substances<\/span> into<\/span> a<\/span> fine<\/span> powder<\/span> and<\/span> mixing<\/span> of<\/span> dry<\/span> medicinal<\/span> substance<\/span> with<\/span> auxiliary<\/span> substances;<\/span> mixing<\/span> of<\/span> powders<\/span> with<\/span> granulating<\/span> liquids;<\/span> granulation;<\/span> drying<\/span> of<\/span> wet<\/span> granules;<\/span> powdering<\/span> of<\/span> dry<\/span> granules.<\/span> Grinding<\/span> and<\/span> mixing<\/span> is<\/span> carried<\/span> out<\/span> in<\/span> mills<\/span> and<\/span> mixers<\/span> of<\/span> various<\/span> designs<\/span> presented<\/span> earlier.<\/span> The<\/span> resulting<\/span> powder<\/span> is<\/span> sifted<\/span> through<\/span> a<\/span> sieve.<\/span>\n\n[\/vc_column_text][\/vc_column][\/vc_row]<\/span><\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][vc_column_text] Wet granulation is subjected to powders having poor flowability and insufficient ability to bond between particles. In both cases, binding solutions are added to the mass, improving the adhesion between the particles. Granulation, or wiping of the wet mass, is carried out in order to compact the powder and obtain uniform grains \u2014 granules…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false,"two_page_speed":[]},"categories":[2232,2175],"tags":[2380,2381,2372,2376,2373,2378,2374,72,73,43,71,68,2239,64,2377,2370,2379,2190,39,67,2375,2192,2240,2371,65,66],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Author Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"GRANULATION PROCESS IN TABLET PRODUCTION<\/a> PHARMACEUTICAL PRODUCTION TECHNOLOGIES<\/a>","rttpg_excerpt":"[vc_row][vc_column][vc_column_text] Wet granulation is subjected to powders having poor flowability and insufficient ability to bond between particles. In both cases, binding solutions are added to the mass, improving the adhesion between the particles. Granulation, or wiping of the wet mass, is carried out in order to compact the powder and obtain uniform grains \u2014 granules...","_links":{"self":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/59550"}],"collection":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/comments?post=59550"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/59550\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/media?parent=59550"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/categories?post=59550"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/tags?post=59550"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}