{"id":59421,"date":"2024-01-16T13:20:35","date_gmt":"1970-01-01T00:00:00","guid":{"rendered":"https:\/\/minipress.ru\/katalog\/?p=59421"},"modified":"2024-01-16T13:20:35","modified_gmt":"1970-01-01T00:00:00","slug":"pelletizing-by-layering","status":"publish","type":"post","link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/pharmaceutical-production-technologies\/pelletizing-by-layering\/","title":{"rendered":"Pelletizing by layering"},"content":{"rendered":"
[vc_row][vc_column][vc_column_text]<\/span>\n\nMicrospheres<\/span> can<\/span> also<\/span> be<\/span> made<\/span> by<\/span> layering<\/span> a<\/span> medicinal<\/span> substance<\/span> on<\/span> inert<\/span> microspheres.<\/span> The<\/span> layering<\/span> process<\/span> is<\/span> a<\/span> sequential<\/span> application<\/span> of<\/span> layers<\/span> of<\/span> a<\/span> medicinal<\/span> substance<\/span> from<\/span> a<\/span> solution,<\/span> suspension<\/span> or<\/span> dry<\/span> powder<\/span> to<\/span> the<\/span> nuclei.<\/span> The<\/span> nuclei<\/span> can<\/span> be<\/span> crystals<\/span> or<\/span> granules<\/span> of<\/span> the<\/span> same<\/span> material<\/span> or<\/span> inert<\/span> particles.<\/span> When<\/span> layered<\/span> from<\/span> a<\/span> solution<\/span> or<\/span> suspension,<\/span> the<\/span> particles<\/span> of<\/span> the<\/span> medicinal<\/span> substance<\/span> are<\/span> dissolved<\/span> or<\/span> suspended<\/span> in<\/span> a<\/span> liquid.<\/span> When<\/span> the<\/span> powder<\/span> is<\/span> layered,<\/span> complete<\/span> dissolution<\/span> does<\/span> not<\/span> occur<\/span> due<\/span> to<\/span> the<\/span> small<\/span> amount<\/span> of<\/span> liquid,<\/span> regardless<\/span> of<\/span> the<\/span> solubility<\/span> of<\/span> the<\/span> active<\/span> component<\/span> in<\/span> the<\/span> liquid.<\/span> When<\/span> powder<\/span> coating<\/span> of<\/span> the<\/span> drug,<\/span> the<\/span> binder<\/span> solution<\/span> is<\/span> first<\/span> sprayed<\/span> onto<\/span> the<\/span> inert<\/span> nuclei,<\/span> and<\/span> then<\/span> the<\/span> powder<\/span> is<\/span> applied.<\/span> By<\/span> adding<\/span> a<\/span> layer-forming<\/span> component,<\/span> the<\/span> layer-by-layer<\/span> formation<\/span> of<\/span> the<\/span> pellet<\/span> is<\/span> carried<\/span> out<\/span> to<\/span> the<\/span> desired<\/span> value.<\/span> Powder<\/span> and<\/span> binders,<\/span> suspensions<\/span> or<\/span> solutions<\/span> are<\/span> suitable<\/span> as<\/span> layering<\/span> components.<\/span> Due<\/span> to<\/span> the<\/span> movement<\/span> of<\/span> pellets<\/span> in<\/span> the<\/span> rotor,<\/span> dense<\/span> layers<\/span> are<\/span> applied.<\/span>\n\n[\/vc_column_text][\/vc_column][\/vc_row]<\/span><\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][vc_column_text] Microspheres can also be made by layering a medicinal substance on inert microspheres. The layering process is a sequential application of layers of a medicinal substance from a solution, suspension or dry powder to the nuclei. The nuclei can be crystals or granules of the same material or inert particles. When layered from a…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false,"two_page_speed":[]},"categories":[2231,2175],"tags":[2380,75,76,77,2381,2372,2376,2373,2378,2374,43,2377,2370,2220,2234,2379,2235,2237,2189,39,63,67,2375,2238,2371,2228,2236],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Author Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"PHARMACEUTICAL PELLET MICROSPHERES<\/a> PHARMACEUTICAL PRODUCTION TECHNOLOGIES<\/a>","rttpg_excerpt":"[vc_row][vc_column][vc_column_text] Microspheres can also be made by layering a medicinal substance on inert microspheres. The layering process is a sequential application of layers of a medicinal substance from a solution, suspension or dry powder to the nuclei. The nuclei can be crystals or granules of the same material or inert particles. When layered from a...","_links":{"self":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/59421"}],"collection":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/comments?post=59421"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/59421\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/media?parent=59421"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/categories?post=59421"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/tags?post=59421"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}