{"id":59392,"date":"2024-01-16T13:20:35","date_gmt":"1970-01-01T00:00:00","guid":{"rendered":"https:\/\/minipress.ru\/katalog\/?p=59392"},"modified":"2024-01-16T13:20:35","modified_gmt":"1970-01-01T00:00:00","slug":"direct-pressing-of-powders-in-production","status":"publish","type":"post","link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/pharmaceutical-production-technologies\/direct-pressing-of-powders-in-production\/","title":{"rendered":"Direct pressing of powders in production"},"content":{"rendered":"
[vc_row][vc_column][vc_column_text]<\/span>\n\nDirect<\/span> pressing<\/span> is<\/span> the<\/span> process<\/span> of<\/span> pressing<\/span> non\u2014granulated<\/span> powders.<\/span> From<\/span> the<\/span> technological<\/span> scheme<\/span> for<\/span> obtaining<\/span> tablets,<\/span> it<\/span> can<\/span> be<\/span> seen<\/span> that<\/span> direct<\/span> pressing<\/span> allows<\/span> you<\/span> to<\/span> exclude<\/span> 3-4<\/span> technological<\/span> operations<\/span> from<\/span> the<\/span> production<\/span> process.<\/span> The<\/span> direct<\/span> pressing<\/span> method<\/span> has<\/span> a<\/span> number<\/span> of<\/span> advantages,<\/span> including:<\/span> reduction<\/span> of<\/span> the<\/span> production<\/span> cycle<\/span> time<\/span> due<\/span> to<\/span> the<\/span> abolition<\/span> of<\/span> a<\/span> number<\/span> of<\/span> operations<\/span> and<\/span> stages;<\/span> use<\/span> of<\/span> less<\/span> equipment;<\/span> reduction<\/span> of<\/span> production<\/span> areas;<\/span> reduction<\/span> of<\/span> energy<\/span> and<\/span> labor<\/span> costs;<\/span> production<\/span> of<\/span> tablets<\/span> from<\/span> moisture-,<\/span> thermolabile<\/span> materials<\/span> and<\/span> incompatible<\/span> substances.<\/span> The<\/span> disadvantages<\/span> of<\/span> the<\/span> direct<\/span> pressing<\/span> method<\/span> include:<\/span> the<\/span> possibility<\/span> of<\/span> delamination<\/span> of<\/span> the<\/span> tablet<\/span> mass;<\/span> changing<\/span> the<\/span> dosage<\/span> when<\/span> pressing<\/span> with<\/span> a<\/span> small<\/span> amount<\/span> of<\/span> active<\/span> substances;<\/span> the<\/span> need<\/span> to<\/span> use<\/span> high<\/span> pressure.<\/span> Some<\/span> of<\/span> these<\/span> disadvantages<\/span> are<\/span> minimized<\/span> when<\/span> tableting<\/span> by<\/span> forcibly<\/span> feeding<\/span> the<\/span> pressed<\/span> substances<\/span> into<\/span> the<\/span> matrix.<\/span>\nHowever,<\/span> despite<\/span> a<\/span> number<\/span> of<\/span> advantages,<\/span> direct<\/span> pressing<\/span> is<\/span> slowly<\/span> being<\/span> introduced<\/span> into<\/span> production.<\/span> This<\/span> is<\/span> explained<\/span> by<\/span> the<\/span> fact<\/span> that<\/span> for<\/span> the<\/span> productive<\/span> operation<\/span> of<\/span> tablet<\/span> machines,<\/span> the<\/span> pressed<\/span> material<\/span> must<\/span> have<\/span> optimal<\/span> technological<\/span> characteristics,<\/span> namely:<\/span> the<\/span> isodiametric<\/span> shape<\/span> of<\/span> crystals,<\/span> good<\/span> flowability<\/span> (at<\/span> least<\/span> 5-6<\/span> g\/s),<\/span> high<\/span> compressibility<\/span> (at<\/span> least<\/span> 0.4\u20140.5<\/span> g\/ml)<\/span> and<\/span> low<\/span> adhesive<\/span> ability<\/span> to<\/span> the<\/span> tablet<\/span> machine<\/span> press<\/span> tool.<\/span> Such<\/span> characteristics<\/span> are<\/span> possessed<\/span> by<\/span> a<\/span> small<\/span> number<\/span> of<\/span> unregulated<\/span> powders:<\/span> bromides,<\/span> sodium<\/span> chloride,<\/span> potassium<\/span> iodide,<\/span> acetylsalicylic<\/span> acid<\/span> and<\/span> some<\/span> other<\/span> preparations<\/span> having<\/span> an<\/span> isodiametric<\/span> (equiaxial)<\/span> particle<\/span> shape<\/span> of<\/span> approximately<\/span> the<\/span> same<\/span> granulometric<\/span> composition<\/span> and,<\/span> as<\/span> a<\/span> rule,<\/span> do<\/span> not<\/span> contain<\/span> a<\/span> large<\/span> number<\/span> of<\/span> small<\/span> fractions.<\/span> Powders<\/span> with<\/span> a<\/span> particle<\/span> size<\/span> of<\/span> 0.5\u20141<\/span> mm<\/span> and<\/span> a<\/span> porosity<\/span> of<\/span> 37%<\/span> are<\/span> best<\/span> suited<\/span> for<\/span> direct<\/span> pressing.<\/span> For<\/span> example,<\/span> to<\/span> obtain<\/span> sodium<\/span> chloride<\/span> tablets,<\/span> the<\/span> oblong<\/span> shape<\/span> of<\/span> the<\/span> particles<\/span> is<\/span> acceptable,<\/span> and<\/span> the<\/span> round<\/span> shape<\/span> of<\/span> this<\/span> substance<\/span> is<\/span> almost<\/span> impossible<\/span> to<\/span> press.<\/span> The<\/span> best<\/span> fluidity<\/span> is<\/span> observed<\/span> in<\/span> coarse<\/span> powders<\/span> with<\/span> an<\/span> equiaxed<\/span> particle<\/span> shape<\/span> and<\/span> low<\/span> porosity,<\/span> such<\/span> as<\/span> lactose,<\/span> phenylsalicitate<\/span> and<\/span> other<\/span> similar<\/span> preparations.<\/span> Such<\/span> preparations<\/span> can<\/span> be<\/span> compressed<\/span> without<\/span> prior<\/span> granulation.<\/span> They<\/span> are<\/span> united<\/span> by<\/span> the<\/span> ability<\/span> to<\/span> pour<\/span> out<\/span> of<\/span> the<\/span> funnel<\/span> evenly<\/span> under<\/span> the<\/span> action<\/span> of<\/span> their<\/span> own<\/span> mass,<\/span> i.e.<\/span> the<\/span> ability<\/span> of<\/span> spontaneous<\/span> dosing,<\/span> as<\/span> well<\/span> as<\/span> fairly<\/span> good<\/span> compressibility.<\/span>\n\n[\/vc_column_text][\/vc_column][\/vc_row]<\/span><\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][vc_column_text] Direct pressing is the process of pressing non\u2014granulated powders. From the technological scheme for obtaining tablets, it can be seen that direct pressing allows you to exclude 3-4 technological operations from the production process. The direct pressing method has a number of advantages, including: reduction of the production cycle time due to the abolition…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false,"two_page_speed":[]},"categories":[2226,2175],"tags":[2380,2381,2372,2376,2373,2378,2374,2227,43,2377,2370,2383,39,245,95,2230,119,96,2229,2375,91,2371,212,2228,89],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Author Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"BASICS OF PRESSING POWDER INTO TABLETS<\/a> PHARMACEUTICAL PRODUCTION TECHNOLOGIES<\/a>","rttpg_excerpt":"[vc_row][vc_column][vc_column_text] Direct pressing is the process of pressing non\u2014granulated powders. From the technological scheme for obtaining tablets, it can be seen that direct pressing allows you to exclude 3-4 technological operations from the production process. The direct pressing method has a number of advantages, including: reduction of the production cycle time due to the abolition...","_links":{"self":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/59392"}],"collection":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/comments?post=59392"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/59392\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/media?parent=59392"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/categories?post=59392"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/tags?post=59392"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}