{"id":59389,"date":"2024-01-16T13:36:03","date_gmt":"1970-01-01T00:00:00","guid":{"rendered":"https:\/\/minipress.ru\/katalog\/?p=59389"},"modified":"2024-01-16T13:36:03","modified_gmt":"1970-01-01T00:00:00","slug":"suppository-bases-and-their-requirements","status":"publish","type":"post","link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/pharmaceutical-production-technologies\/suppository-bases-and-their-requirements\/","title":{"rendered":"Suppository bases and their requirements"},"content":{"rendered":"
[vc_row][vc_column][vc_column_text]<\/span>\n\nFrom<\/span> a<\/span> physico-chemical<\/span> point<\/span> of<\/span> view,<\/span> suppositories<\/span> are<\/span> considered<\/span> as<\/span> dispersed<\/span> systems<\/span> consisting<\/span> of<\/span> a<\/span> dispersion<\/span> medium,<\/span> represented<\/span> by<\/span> the<\/span> basis<\/span> of<\/span> the<\/span> Dispersed<\/span> phase,<\/span> in<\/span> the<\/span> role<\/span> of<\/span> which<\/span> medicinal<\/span> substances<\/span> act.<\/span> Depending<\/span> on<\/span> the<\/span> properties<\/span> of<\/span> medicinal<\/span> substances,<\/span> dispersed<\/span> systems<\/span> of<\/span> suppositories<\/span> can<\/span> be<\/span> either<\/span> homogeneous<\/span> or<\/span> heterogeneous.<\/span> Homogeneous<\/span> systems<\/span> are<\/span> formed<\/span> when<\/span> the<\/span> medicinal<\/span> substance<\/span> is<\/span> dissolved<\/span> in<\/span> the<\/span> base.<\/span> Heterogeneous<\/span> systems<\/span> are<\/span> formed<\/span> in<\/span> the<\/span> case<\/span> of<\/span> the<\/span> introduction<\/span> of<\/span> medecine<\/span> into<\/span> the<\/span> base<\/span> by<\/span> the<\/span> type<\/span> of<\/span> emulsion<\/span> or<\/span> suspension.<\/span> In<\/span> the<\/span> structure<\/span> of<\/span> suppositories,<\/span> there<\/span> are<\/span> basic<\/span> (medicinal<\/span> substances)<\/span> and<\/span> auxiliary<\/span> (carriers<\/span> or<\/span> base)<\/span> components.<\/span> There<\/span> are<\/span> a<\/span> number<\/span> of<\/span> requirements<\/span> for<\/span> suppository<\/span> bases:<\/span> the<\/span> bases<\/span> must<\/span> maintain<\/span> sufficient<\/span> hardness<\/span> at<\/span> room<\/span> temperature;<\/span> the<\/span> melting<\/span> (dissolution)<\/span> temperature<\/span> of<\/span> the<\/span> base<\/span> must<\/span> be<\/span> close<\/span> to<\/span> the<\/span> temperature<\/span> of<\/span> the<\/span> human<\/span> body;<\/span> the<\/span> bases<\/span> must<\/span> not<\/span> irritate<\/span> the<\/span> rectal<\/span> mucosa<\/span> or<\/span> cause<\/span> undesirable<\/span> phenomena,<\/span> i.e.<\/span> they<\/span> must<\/span> be<\/span> physiologically<\/span> indifferent;<\/span> suppository<\/span> bases<\/span> must<\/span> not<\/span> interfere<\/span> with<\/span> the<\/span> release<\/span> and<\/span> therapeutic<\/span> effect<\/span> of<\/span> the<\/span> medicinal<\/span> substance;<\/span> the<\/span> bases<\/span> should<\/span> not<\/span> interact<\/span> with<\/span> medicinal<\/span> substances<\/span> injected<\/span> into<\/span> the<\/span> suppository<\/span> mass.<\/span>\n\n[\/vc_column_text][\/vc_column][\/vc_row]<\/span><\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][vc_column_text] From a physico-chemical point of view, suppositories are considered as dispersed systems consisting of a dispersion medium, represented by the basis of the Dispersed phase, in the role of which medicinal substances act. Depending on the properties of medicinal substances, dispersed systems of suppositories can be either homogeneous or heterogeneous. Homogeneous systems are formed…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false,"two_page_speed":[]},"categories":[2215,2175],"tags":[2380,2381,2372,2376,2373,2378,2374,43,2377,2370,2222,2220,2191,51,2224,2379,39,2223,2375,2225,2371,2221,140],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Author Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"MAKING SUPPOSITORIES IN PRODUCTION<\/a> PHARMACEUTICAL PRODUCTION TECHNOLOGIES<\/a>","rttpg_excerpt":"[vc_row][vc_column][vc_column_text] From a physico-chemical point of view, suppositories are considered as dispersed systems consisting of a dispersion medium, represented by the basis of the Dispersed phase, in the role of which medicinal substances act. Depending on the properties of medicinal substances, dispersed systems of suppositories can be either homogeneous or heterogeneous. Homogeneous systems are formed...","_links":{"self":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/59389"}],"collection":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/comments?post=59389"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/59389\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/media?parent=59389"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/categories?post=59389"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/tags?post=59389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}