{"id":58975,"date":"2024-01-16T13:36:03","date_gmt":"1970-01-01T00:00:00","guid":{"rendered":"https:\/\/minipress.ru\/katalog\/?p=58975"},"modified":"2024-01-16T13:36:03","modified_gmt":"1970-01-01T00:00:00","slug":"force-to-push-tablets-out-of-the-matrix","status":"publish","type":"post","link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/pharmaceutical-production-technologies\/force-to-push-tablets-out-of-the-matrix\/","title":{"rendered":"Force to push tablets out of the matrix"},"content":{"rendered":"
[vc_row][vc_column][vc_column_text]<\/span>\n\nTo<\/span> push<\/span> the<\/span> compressed<\/span> tablet<\/span> out<\/span> of<\/span> the<\/span> matrix,<\/span> it<\/span> is<\/span> required<\/span> to<\/span> expend<\/span> force<\/span> to<\/span> overcome<\/span> friction<\/span> and<\/span> adhesion<\/span> between<\/span> the<\/span> side<\/span> surface<\/span> of<\/span> the<\/span> tablet<\/span> and<\/span> the<\/span> wall<\/span> of<\/span> the<\/span> matrix.<\/span> Taking<\/span> into<\/span> account<\/span> the<\/span> magnitude<\/span> of<\/span> the<\/span> ejection<\/span> force,<\/span> additives<\/span> of<\/span> antifriction<\/span> (sliding<\/span> or<\/span> lubricating)<\/span> substances<\/span> are<\/span> predicted.<\/span> As<\/span> an<\/span> example,<\/span> the<\/span> results<\/span> of<\/span> determining<\/span> the<\/span> technological<\/span> characteristics<\/span> of<\/span> round-shaped<\/span> substances<\/span> are<\/span> given.<\/span> Powders<\/span> with<\/span> rounded<\/span> particles<\/span> with<\/span> a<\/span> basic<\/span> particle<\/span> size<\/span> of<\/span> more<\/span> than<\/span> 100<\/span> microns<\/span> (ranitidine<\/span> g\/cl,<\/span> carbamazepine,<\/span> phenazepam)<\/span> have<\/span> high<\/span> (8-9<\/span> g\/s)<\/span> flowability,<\/span> high<\/span> volume<\/span> density<\/span> before<\/span> and<\/span> after<\/span> compaction,<\/span> but<\/span> insignificant<\/span> compressibility<\/span> and<\/span> a<\/span> small<\/span> compaction<\/span> coefficient.<\/span>\nPhenazepam<\/span> has<\/span> a<\/span> slightly<\/span> lower<\/span> flowability<\/span> value<\/span> (8<\/span> g\/s),<\/span> probably<\/span> because<\/span> it<\/span> contains<\/span> more<\/span> small<\/span> fractions<\/span> and<\/span> does<\/span> not<\/span> contain<\/span> particles<\/span> larger<\/span> than<\/span> 250<\/span> microns,<\/span> which<\/span> are<\/span> present<\/span> in<\/span> ranitidine<\/span> and<\/span> carbamazepine.<\/span>\n\n[\/vc_column_text][\/vc_column][\/vc_row]<\/span><\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][vc_column_text] To push the compressed tablet out of the matrix, it is required to expend force to overcome friction and adhesion between the side surface of the tablet and the wall of the matrix. Taking into account the magnitude of the ejection force, additives of antifriction (sliding or lubricating) substances are predicted. As an example,…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false,"two_page_speed":[]},"categories":[2175,2199],"tags":[2201,2380,2381,2372,2376,2373,2378,2374,2202,2200,210,43,2377,2370,2379,39,245,95,2375,114,91,2371,58,158,212,2203,89],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Author Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"PHARMACEUTICAL PRODUCTION TECHNOLOGIES<\/a> TABLET MANUFACTURING TECHNOLOGY<\/a>","rttpg_excerpt":"[vc_row][vc_column][vc_column_text] To push the compressed tablet out of the matrix, it is required to expend force to overcome friction and adhesion between the side surface of the tablet and the wall of the matrix. Taking into account the magnitude of the ejection force, additives of antifriction (sliding or lubricating) substances are predicted. As an example,...","_links":{"self":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/58975"}],"collection":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/comments?post=58975"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/58975\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/media?parent=58975"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/categories?post=58975"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/tags?post=58975"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}