{"id":58954,"date":"2024-01-16T13:21:07","date_gmt":"1970-01-01T00:00:00","guid":{"rendered":"https:\/\/minipress.ru\/katalog\/?p=58954"},"modified":"2024-01-16T13:21:07","modified_gmt":"1970-01-01T00:00:00","slug":"basic-requirements-for-tablets","status":"publish","type":"post","link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/pharmaceutical-production-technologies\/basic-requirements-for-tablets\/","title":{"rendered":"Basic requirements for tablets"},"content":{"rendered":"
[vc_row][vc_column][vc_column_text]<\/span>\n\nThe<\/span> following<\/span> requirements<\/span> are<\/span> imposed<\/span> on<\/span> tablets:<\/span> dosing<\/span> accuracy<\/span> \u2014<\/span> uniformity<\/span> (uniformity)<\/span> of<\/span> the<\/span> distribution<\/span> of<\/span> the<\/span> active<\/span> substance<\/span> in<\/span> the<\/span> tablet,<\/span> the<\/span> correctness<\/span> of<\/span> the<\/span> weight<\/span> of<\/span> both<\/span> the<\/span> tablet<\/span> itself<\/span> and<\/span> the<\/span> medicinal<\/span> substances<\/span> included<\/span> in<\/span> it;<\/span>\nmechanical<\/span> strength<\/span> \u2014<\/span> hardness,<\/span> brittleness,<\/span> fragility<\/span> \u2014<\/span> characterize<\/span> the<\/span> quality<\/span> of<\/span> tablets;<\/span> tablets<\/span> must<\/span> have<\/span> sufficient<\/span> strength<\/span> to<\/span> remain<\/span> intact<\/span> under<\/span> mechanical<\/span> influences<\/span> during<\/span> packaging,<\/span> transportation<\/span> and<\/span> storage;<\/span>\ndisintegration<\/span> or<\/span> solubility<\/span> \u2014<\/span> the<\/span> ability<\/span> to<\/span> disintegrate<\/span> or<\/span> dissolve<\/span> within<\/span> the<\/span> time<\/span> limits<\/span> established<\/span> by<\/span> the<\/span> relevant<\/span> scientific<\/span> and<\/span> technical<\/span> documentation<\/span> (NTD)<\/span> for<\/span> certain<\/span> types<\/span> of<\/span> tablets.<\/span> The<\/span> accuracy<\/span> of<\/span> dosing<\/span> depends<\/span> on<\/span> the<\/span> uniformity<\/span> of<\/span> the<\/span> tableted<\/span> mass,<\/span> which<\/span> is<\/span> ensured<\/span> by<\/span> careful<\/span> mixing<\/span> of<\/span> medicinal<\/span> and<\/span> auxiliary<\/span> substances<\/span> and<\/span> their<\/span> uniform<\/span> distribution<\/span> in<\/span> the<\/span> total<\/span> mass.<\/span> The<\/span> accuracy<\/span> of<\/span> dosing<\/span> also<\/span> depends<\/span> on<\/span> the<\/span> speed<\/span> and<\/span> reliability<\/span> of<\/span> filling<\/span> the<\/span> matrix<\/span> slot<\/span> of<\/span> the<\/span> tablet<\/span> machine.<\/span> If<\/span> less<\/span> material<\/span> is<\/span> poured<\/span> out<\/span> over<\/span> the<\/span> matrix<\/span> hole<\/span> during<\/span> the<\/span> short<\/span> stay<\/span> of<\/span> the<\/span> funnel<\/span> than<\/span> the<\/span> matrix<\/span> socket<\/span> can<\/span> accept,<\/span> the<\/span> mass<\/span> of<\/span> the<\/span> tablets<\/span> received<\/span> will<\/span> be<\/span> insufficient.<\/span> The<\/span> required<\/span> filling<\/span> rate<\/span> of<\/span> the<\/span> matrix<\/span> socket<\/span> depends<\/span> on<\/span> the<\/span> shape<\/span> of<\/span> the<\/span> funnel,<\/span> the<\/span> angle<\/span> of<\/span> the<\/span> slope<\/span> and<\/span> whether<\/span> the<\/span> particles<\/span> of<\/span> the<\/span> tableted<\/span> mass<\/span> have<\/span> sufficient<\/span> slip.<\/span> Often,<\/span> the<\/span> friction<\/span> forces<\/span> between<\/span> individual<\/span> particles<\/span> due<\/span> to<\/span> the<\/span> roughness<\/span> of<\/span> their<\/span> surface<\/span> are<\/span> so<\/span> great<\/span> that<\/span> the<\/span> matrix<\/span> socket<\/span> is<\/span> not<\/span> completely<\/span> filled<\/span> or<\/span> is<\/span> not<\/span> filled<\/span> at<\/span> all<\/span> due<\/span> to<\/span> the<\/span> delay<\/span> of<\/span> the<\/span> powder<\/span> in<\/span> the<\/span> funnel.<\/span>\n\n[\/vc_column_text][\/vc_column][\/vc_row]<\/span><\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][vc_column_text] The following requirements are imposed on tablets: dosing accuracy \u2014 uniformity (uniformity) of the distribution of the active substance in the tablet, the correctness of the weight of both the tablet itself and the medicinal substances included in it; mechanical strength \u2014 hardness, brittleness, fragility \u2014 characterize the quality of tablets; tablets must have…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false,"two_page_speed":[]},"categories":[2175,2199],"tags":[2201,2380,2381,2372,2376,2373,2378,2374,2202,2200,210,43,2377,2370,2379,39,245,95,2375,114,91,2371,58,158,212,2203,89],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Author Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"PHARMACEUTICAL PRODUCTION TECHNOLOGIES<\/a> TABLET MANUFACTURING TECHNOLOGY<\/a>","rttpg_excerpt":"[vc_row][vc_column][vc_column_text] The following requirements are imposed on tablets: dosing accuracy \u2014 uniformity (uniformity) of the distribution of the active substance in the tablet, the correctness of the weight of both the tablet itself and the medicinal substances included in it; mechanical strength \u2014 hardness, brittleness, fragility \u2014 characterize the quality of tablets; tablets must have...","_links":{"self":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/58954"}],"collection":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/comments?post=58954"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/58954\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/media?parent=58954"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/categories?post=58954"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/tags?post=58954"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}