{"id":58945,"date":"2024-01-16T11:17:01","date_gmt":"1970-01-01T00:00:00","guid":{"rendered":"https:\/\/minipress.ru\/katalog\/?p=58945"},"modified":"2024-01-16T11:17:01","modified_gmt":"1970-01-01T00:00:00","slug":"homogenization-of-ointments-and-creams","status":"publish","type":"post","link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/pharmaceutical-production-technologies\/homogenization-of-ointments-and-creams\/","title":{"rendered":"Homogenization of ointments and creams"},"content":{"rendered":"
[vc_row][vc_column][vc_column_text]<\/span>\n\nThe<\/span> next<\/span> stage<\/span> in<\/span> the<\/span> production<\/span> of<\/span> ointments<\/span> is<\/span> homogenization.<\/span> This<\/span> is<\/span> a<\/span> specific<\/span> stage,<\/span> since<\/span> when<\/span> mixing,<\/span> the<\/span> desired<\/span> degree<\/span> of<\/span> dispersion<\/span> of<\/span> medicinal<\/span> substances<\/span> is<\/span> not<\/span> always<\/span> achieved.<\/span> For<\/span> homogenization,<\/span> various<\/span> equipment<\/span> is<\/span> used,<\/span> such<\/span> as<\/span> roller<\/span> or<\/span> disc<\/span> masers,<\/span> millstones<\/span> and<\/span> colloidal<\/span> mills,<\/span> as<\/span> well<\/span> as<\/span> homogenizers-dispersants.<\/span>\nRoller<\/span> mazeterki<\/span> have<\/span> two<\/span> or<\/span> three<\/span> rolls<\/span> with<\/span> a<\/span> smooth<\/span> surface,<\/span> rotating<\/span> towards<\/span> each<\/span> other<\/span> at<\/span> different<\/span> speeds,<\/span> ensuring<\/span> the<\/span> transition<\/span> of<\/span> ointment<\/span> from<\/span> shaft<\/span> to<\/span> shaft<\/span> and<\/span> increasing<\/span> the<\/span> friction<\/span> between<\/span> them.<\/span> Rolls<\/span> are<\/span> made<\/span> of<\/span> porcelain,<\/span> basalt<\/span> or<\/span> metal.<\/span> To<\/span> maintain<\/span> the<\/span> optimal<\/span> temperature<\/span> of<\/span> the<\/span> ointment<\/span> entering<\/span> the<\/span> rolls,<\/span> they<\/span> are<\/span> made<\/span> hollow<\/span> so<\/span> that,<\/span> if<\/span> necessary,<\/span> water<\/span> can<\/span> be<\/span> supplied<\/span> inside.<\/span>\nMazeterka<\/span> is<\/span> a<\/span> system<\/span> of<\/span> three<\/span> rolls<\/span> in<\/span> contact<\/span> with<\/span> each<\/span> other,<\/span> the<\/span> axes<\/span> of<\/span> which<\/span> lie<\/span> in<\/span> the<\/span> same<\/span> plane.<\/span> The<\/span> two<\/span> extreme<\/span> rolls<\/span> are<\/span> pressed<\/span> against<\/span> the<\/span> middle<\/span> one<\/span> by<\/span> springs.<\/span> The<\/span> gap<\/span> between<\/span> the<\/span> middle<\/span> and<\/span> extreme<\/span> rolls<\/span> is<\/span> adjustable.<\/span> Ointments<\/span> and<\/span> pastes<\/span> are<\/span> rubbed<\/span> in<\/span> the<\/span> contact<\/span> zone<\/span> of<\/span> the<\/span> rolls.<\/span> The<\/span> crushed<\/span> ointment<\/span> is<\/span> scraped<\/span> off<\/span> the<\/span> roll<\/span> with<\/span> a<\/span> scraper<\/span> mounted<\/span> on<\/span> the<\/span> body<\/span> of<\/span> the<\/span> ointment.<\/span> The<\/span> grinding<\/span> process<\/span> proceeds<\/span> in<\/span> three<\/span> stages:<\/span> solid<\/span> particles<\/span> or<\/span> lumps<\/span> are<\/span> crushed<\/span> or<\/span> crushed<\/span> in<\/span> the<\/span> cracks<\/span> between<\/span> rolls<\/span> I<\/span> and<\/span> II;<\/span> the<\/span> grinding<\/span> action<\/span> is<\/span> further<\/span> enhanced<\/span> by<\/span> the<\/span> grinding<\/span> action<\/span> of<\/span> rolls<\/span> II<\/span> and<\/span> III<\/span> due<\/span> to<\/span> the<\/span> higher<\/span> rotation<\/span> speed;<\/span> the<\/span> grinding<\/span> action<\/span> is<\/span> enhanced<\/span> by<\/span> additional<\/span> oscillatory<\/span> movements<\/span> of<\/span> the<\/span> III<\/span> roll<\/span> along<\/span> its<\/span> axis.<\/span> It<\/span> is<\/span> very<\/span> important<\/span> that<\/span> the<\/span> rolls<\/span> stand<\/span> at<\/span> an<\/span> appropriate<\/span> distance<\/span> from<\/span> each<\/span> other<\/span> and<\/span> the<\/span> gaps<\/span> between<\/span> rolls<\/span> I<\/span> and<\/span> II,<\/span> as<\/span> well<\/span> as<\/span> between<\/span> rolls<\/span> II<\/span> and<\/span> III,<\/span> are<\/span> in<\/span> the<\/span> correct<\/span> ratio.<\/span> To<\/span> change<\/span> the<\/span> size<\/span> of<\/span> the<\/span> gaps,<\/span> the<\/span> bearings<\/span> of<\/span> rolls<\/span> I<\/span> and<\/span> III<\/span> are<\/span> moved<\/span> using<\/span> adjusting<\/span> screws.<\/span> The<\/span> mazeterka<\/span> also<\/span> has<\/span> a<\/span> safety<\/span> device<\/span> that<\/span> automatically<\/span> stops<\/span> it<\/span> when<\/span> foreign<\/span> objects<\/span> get<\/span> into<\/span> the<\/span> gaps<\/span> between<\/span> the<\/span> rolls.<\/span> The<\/span> productivity<\/span> of<\/span> the<\/span> three-roll<\/span> ointment<\/span> is<\/span> about<\/span> 50<\/span> kg<\/span> of<\/span> ointment<\/span> per<\/span> hour.<\/span> The<\/span> millstone<\/span> mill<\/span> consists<\/span> of<\/span> two<\/span> millstones,<\/span> where<\/span> the<\/span> upper<\/span> one<\/span> is<\/span> cast<\/span> together<\/span> with<\/span> the<\/span> loading<\/span> funnel<\/span> and<\/span> is<\/span> stationary,<\/span> and<\/span> the<\/span> lower<\/span> millstone<\/span> rotates<\/span> in<\/span> the<\/span> horizontal<\/span> direction.<\/span> The<\/span> ointment<\/span> is<\/span> homogenized<\/span> in<\/span> the<\/span> lumen<\/span> between<\/span> the<\/span> millstones<\/span> and<\/span> squeezed<\/span> out<\/span> to<\/span> the<\/span> edges,<\/span> where<\/span> it<\/span> is<\/span> collected<\/span> into<\/span> the<\/span> receiver<\/span> using<\/span> a<\/span> scraper.<\/span> The<\/span> degree<\/span> of<\/span> dispersion<\/span> is<\/span> determined<\/span> by<\/span> the<\/span> distance<\/span> between<\/span> the<\/span> millstones.<\/span> The<\/span> mill<\/span> capacity<\/span> is<\/span> 60-80<\/span> kg\/h.<\/span> Colloidal<\/span> mills<\/span> of<\/span> various<\/span> designs<\/span> are<\/span> used<\/span> to<\/span> prepare<\/span> emulsions<\/span> and<\/span> suspensions<\/span> containing<\/span> insoluble<\/span> solids.<\/span> In<\/span> modern<\/span> colloidal<\/span> mills,<\/span> grinding<\/span> takes<\/span> place<\/span> in<\/span> a<\/span> liquid<\/span> medium<\/span> by<\/span> means<\/span> of<\/span> impact<\/span> or<\/span> rubbing.<\/span> The<\/span> ratio<\/span> of<\/span> the<\/span> solid<\/span> and<\/span> liquid<\/span> phases<\/span> ranges<\/span> from<\/span> 1:2<\/span> to<\/span> 1:6,<\/span> depending<\/span> on<\/span> the<\/span> properties<\/span> of<\/span> the<\/span> solid<\/span> crushed<\/span> material.<\/span> Colloidal<\/span> grinding<\/span> is<\/span> a<\/span> complex<\/span> and<\/span> little-studied<\/span> process.<\/span> The<\/span> designs<\/span> of<\/span> colloidal<\/span> mills<\/span> with<\/span> industrial<\/span> applications<\/span> are<\/span> few.<\/span> The<\/span> greatest<\/span> interest<\/span> for<\/span> the<\/span> pharmaceutical<\/span> industry<\/span> is<\/span> represented<\/span> by<\/span> bilny<\/span> and<\/span> vibrocavitationic<\/span> colloidal<\/span> mills.<\/span>\n\n[\/vc_column_text][\/vc_column][\/vc_row]<\/span><\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][vc_column_text] The next stage in the production of ointments is homogenization. This is a specific stage, since when mixing, the desired degree of dispersion of medicinal substances is not always achieved. For homogenization, various equipment is used, such as roller or disc masers, millstones and colloidal mills, as well as homogenizers-dispersants. Roller mazeterki have two…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false,"two_page_speed":[]},"categories":[3186,3037,3181,2997,3015,2175,2188,3182],"tags":[2380,2381,2372,2376,2373,2197,2378,2374,156,193,2196,43,2193,2195,2377,2370,2191,2379,155,194,2375,2198,2192,2371,2194],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Author Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"ANTIFUNGAL OINTMENTS<\/a> BUY HOMOGENIZER<\/a> HEPARIN OINTMENT<\/a> LABORATORY HOMOGENIZER<\/a> PHARMACEUTICAL HOMOGENIZERS<\/a> PHARMACEUTICAL PRODUCTION TECHNOLOGIES<\/a> PRODUCTION OF CREAMS AND OINTMENTS EQUIPMENT<\/a> STELLANINE OINTMENT<\/a>","rttpg_excerpt":"[vc_row][vc_column][vc_column_text] The next stage in the production of ointments is homogenization. This is a specific stage, since when mixing, the desired degree of dispersion of medicinal substances is not always achieved. For homogenization, various equipment is used, such as roller or disc masers, millstones and colloidal mills, as well as homogenizers-dispersants. Roller mazeterki have two...","_links":{"self":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/58945"}],"collection":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/comments?post=58945"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/58945\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/media?parent=58945"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/categories?post=58945"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/tags?post=58945"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}