{"id":58944,"date":"2024-01-16T11:17:01","date_gmt":"1970-01-01T00:00:00","guid":{"rendered":"https:\/\/minipress.ru\/katalog\/?p=58944"},"modified":"2024-01-16T11:17:01","modified_gmt":"1970-01-01T00:00:00","slug":"hydrophilic-bases-for-ointments-and-creams","status":"publish","type":"post","link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/pharmaceutical-production-technologies\/hydrophilic-bases-for-ointments-and-creams\/","title":{"rendered":"Hydrophilic bases for ointments and creams"},"content":{"rendered":"
[vc_row][vc_column][vc_column_text]<\/span>\n\nHydrophilic<\/span> bases<\/span> are<\/span> mixed<\/span> with<\/span> water<\/span> in<\/span> any<\/span> ratio.<\/span> The<\/span> following<\/span> ointment<\/span> bases<\/span> are<\/span> hydrophilic:<\/span> solutions<\/span> and<\/span> gels<\/span> of<\/span> polysaccharides;<\/span> solutions<\/span> and<\/span> gels<\/span> of<\/span> natural<\/span> and<\/span> synthetic<\/span> polymers;<\/span> phytosterol<\/span> gels;<\/span> gels<\/span> of<\/span> clay<\/span> minerals;<\/span> solutions<\/span> and<\/span> gels<\/span> of<\/span> proteins.<\/span> The<\/span> advantages<\/span> of<\/span> hydrophilic<\/span> bases<\/span> are:<\/span> the<\/span> possibility<\/span> of<\/span> introducing<\/span> a<\/span> significant<\/span> amount<\/span> of<\/span> aqueous<\/span> solutions<\/span> of<\/span> medicinal<\/span> substances;<\/span> ease<\/span> of<\/span> release<\/span> of<\/span> medicinal<\/span> substances,<\/span> which<\/span> ensures<\/span> their<\/span> high<\/span> bioavailability;<\/span> good<\/span> absorbency<\/span> into<\/span> the<\/span> skin,<\/span> the<\/span> bases<\/span> are<\/span> easily<\/span> removed<\/span> from<\/span> the<\/span> application<\/span> site<\/span> and<\/span> washed<\/span> off<\/span> with<\/span> water<\/span> from<\/span> the<\/span> skin.<\/span>\nThe<\/span> disadvantages<\/span> of<\/span> hydrophilic<\/span> bases<\/span> include<\/span> microbial<\/span> contamination<\/span> and<\/span> rapid<\/span> drying<\/span> (this<\/span> property<\/span> does<\/span> not<\/span> apply<\/span> to<\/span> polyethylene<\/span> oxides),<\/span> as<\/span> well<\/span> as<\/span> incompatibility<\/span> with<\/span> a<\/span> number<\/span> of<\/span> medicinal<\/span> substances<\/span> and<\/span> susceptibility<\/span> to<\/span> syneresis,<\/span> a<\/span> phenomenon<\/span> in<\/span> which<\/span> the<\/span> liquid<\/span> phase<\/span> is<\/span> released.<\/span> Solutions<\/span> and<\/span> gels<\/span> of<\/span> polysaccharides<\/span> as<\/span> bases<\/span> for<\/span> ointments.<\/span> Recently,<\/span> microcrystalline<\/span> cellulose<\/span> has<\/span> been<\/span> used<\/span> in<\/span> our<\/span> country<\/span> and<\/span> abroad<\/span> to<\/span> prepare<\/span> the<\/span> bases<\/span> for<\/span> ointments,<\/span> which<\/span> swells<\/span> in<\/span> water,<\/span> forming<\/span> viscoplastic<\/span> gels.<\/span> However,<\/span> cellulose<\/span> esters<\/span> have<\/span> found<\/span> the<\/span> most<\/span> widespread<\/span> use<\/span> in<\/span> the<\/span> production<\/span> of<\/span> bases<\/span> for<\/span> ointments:<\/span> methyl<\/span> cellulose<\/span> (MC),<\/span> sodium<\/span> salt<\/span> of<\/span> carbosimethyl<\/span> cellulose<\/span> (Na-CMC),<\/span> etc.<\/span> Cellulose<\/span> esters.<\/span> Methylcellulose<\/span> and<\/span> sodium-carboxymethylcellulose<\/span> gels<\/span> can<\/span> be<\/span> used<\/span> as<\/span> ointment<\/span> bases.<\/span> Methylcellulose<\/span> gels<\/span> are<\/span> used<\/span> at<\/span> a<\/span> concentration<\/span> of<\/span> 4-6%.<\/span> To<\/span> prevent<\/span> drying,<\/span> glycerin<\/span> is<\/span> added<\/span> to<\/span> them.<\/span> Methylcellulose<\/span> gels<\/span> form<\/span> films<\/span> on<\/span> the<\/span> skin,<\/span> so<\/span> they<\/span> are<\/span> used<\/span> to<\/span> prepare<\/span> protective<\/span> ointments.<\/span> Sodium-carboxymethylcellulose<\/span> gels<\/span> are<\/span> used<\/span> in<\/span> the<\/span> same<\/span> concentration<\/span> of<\/span> 4-6%.<\/span> They<\/span> also<\/span> include<\/span> glycerin.<\/span> The<\/span> pH<\/span> value<\/span> of<\/span> these<\/span> gels<\/span> is<\/span> 6.5\u20148.0,<\/span> and<\/span> therefore<\/span> the<\/span> acidic<\/span> reaction<\/span> of<\/span> the<\/span> epidermis<\/span> medium<\/span> may<\/span> also<\/span> change.<\/span> The<\/span> advantage<\/span> of<\/span> these<\/span> bases<\/span> is<\/span> the<\/span> absence<\/span> of<\/span> irritating<\/span> and<\/span> sensitizing<\/span> effects,<\/span> harmlessness,<\/span> the<\/span> possibility<\/span> of<\/span> using<\/span> them<\/span> to<\/span> obtain<\/span> dry<\/span> ointments-concentrates;<\/span> they<\/span> have<\/span> high<\/span> osmotic<\/span> activity<\/span> and<\/span> are<\/span> used<\/span> in<\/span> ointments<\/span> for<\/span> the<\/span> treatment<\/span> of<\/span> wounds.<\/span> The<\/span> disadvantages<\/span> of<\/span> these<\/span> bases<\/span> include<\/span> incompatibility<\/span> with<\/span> many<\/span> medicinal<\/span> substances<\/span> (resorcinol,<\/span> tannin,<\/span> iodine,<\/span> heavy<\/span> metal<\/span> salts,<\/span> etc.).<\/span> Microbial<\/span> polysaccharide<\/span> gels<\/span> are<\/span> obtained<\/span> from<\/span> dextran<\/span> polysaccharide,<\/span> which<\/span> is<\/span> formed<\/span> as<\/span> a<\/span> result<\/span> of<\/span> the<\/span> vital<\/span> activity<\/span> of<\/span> the<\/span> microbes<\/span> Leuconostok<\/span> mesentervides<\/span> and<\/span> L.<\/span> dextranicus.<\/span>\n\n[\/vc_column_text][\/vc_column][\/vc_row]<\/span><\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][vc_column_text] Hydrophilic bases are mixed with water in any ratio. The following ointment bases are hydrophilic: solutions and gels of polysaccharides; solutions and gels of natural and synthetic polymers; phytosterol gels; gels of clay minerals; solutions and gels of proteins. The advantages of hydrophilic bases are: the possibility of introducing a significant amount of aqueous…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false,"two_page_speed":[]},"categories":[2175,2188,3182],"tags":[2380,2381,2372,2376,2373,2197,2378,2374,156,193,2196,43,2193,2195,2377,2370,2191,2379,155,194,2375,2198,2192,2371,2194],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Author Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"PHARMACEUTICAL PRODUCTION TECHNOLOGIES<\/a> PRODUCTION OF CREAMS AND OINTMENTS EQUIPMENT<\/a> STELLANINE OINTMENT<\/a>","rttpg_excerpt":"[vc_row][vc_column][vc_column_text] Hydrophilic bases are mixed with water in any ratio. The following ointment bases are hydrophilic: solutions and gels of polysaccharides; solutions and gels of natural and synthetic polymers; phytosterol gels; gels of clay minerals; solutions and gels of proteins. The advantages of hydrophilic bases are: the possibility of introducing a significant amount of aqueous...","_links":{"self":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/58944"}],"collection":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/comments?post=58944"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/58944\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/media?parent=58944"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/categories?post=58944"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/tags?post=58944"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}