{"id":58578,"date":"2024-01-16T13:36:10","date_gmt":"1970-01-01T00:00:00","guid":{"rendered":"https:\/\/minipress.ru\/katalog\/?p=58578"},"modified":"2024-01-17T16:49:25","modified_gmt":"2024-01-17T13:49:25","slug":"standardization-of-ointments-in-production","status":"publish","type":"post","link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/pharmaceutical-production-technologies\/standardization-of-ointments-in-production\/","title":{"rendered":"Standardization of ointments in production"},"content":{"rendered":"
Intra-shop<\/span> control<\/span> of<\/span> ointments<\/span> is<\/span> carried<\/span> out<\/span> at<\/span> almost<\/span> every<\/span> stage<\/span> of<\/span> production<\/span> and<\/span> especially<\/span> before<\/span> packing<\/span> the<\/span> drug.<\/span> The<\/span> final<\/span> conclusion<\/span> on<\/span> all<\/span> indicators<\/span> of<\/span> the<\/span> quality<\/span> of<\/span> finished<\/span> products<\/span> is<\/span> given<\/span> by<\/span> the<\/span> quality<\/span> control<\/span> department<\/span> of<\/span> the<\/span> plant.<\/span> In<\/span> the<\/span> conditions<\/span> of<\/span> industrial<\/span> production,<\/span> the<\/span> test<\/span> is<\/span> carried<\/span> out<\/span> in<\/span> accordance<\/span> with<\/span> the<\/span> requirements<\/span> of<\/span> the<\/span> general<\/span> article<\/span> of<\/span> the<\/span> State<\/span> Pharmacopoeia<\/span> (GF)<\/span> for<\/span> ointments,<\/span> as<\/span> well<\/span> as<\/span> the<\/span> requirements<\/span> included<\/span> in<\/span> the<\/span> articles<\/span> of<\/span> the<\/span> GF<\/span> for<\/span> individual<\/span> names<\/span> of<\/span> ointments.<\/span> The<\/span> ointment<\/span> is<\/span> standardized<\/span> in<\/span> appearance,<\/span> uniformity,<\/span> content<\/span> of<\/span> medicinal<\/span> substances,<\/span> pH<\/span> value,<\/span> degree<\/span> of<\/span> dispersion<\/span> of<\/span> solid<\/span> particles,<\/span> colloidal<\/span> stability<\/span> and<\/span> thermal<\/span> stability.<\/span> The<\/span> company<\/span> controls<\/span> the<\/span> appearance,<\/span> smell<\/span> and<\/span> characteristic<\/span> organoleptic<\/span> properties<\/span> (if<\/span> any)<\/span> of<\/span> ointments<\/span> and<\/span> other<\/span> soft<\/span> medicines.<\/span> They<\/span> should<\/span> not<\/span> have<\/span> a<\/span> rancid<\/span> smell,<\/span> as<\/span> well<\/span> as<\/span> (if<\/span> there<\/span> are<\/span> no<\/span> other<\/span> indications<\/span> in<\/span> private<\/span> articles)<\/span> signs<\/span> of<\/span> physical<\/span> instability<\/span> (aggregation<\/span> of<\/span> particles,<\/span> coalescence,<\/span> coagulation<\/span> and<\/span> stratification).<\/span> The<\/span> amount<\/span> of<\/span> medicinal<\/span> substances<\/span> in<\/span> ointments<\/span> is<\/span> determined<\/span> by<\/span> the<\/span> methods<\/span> given<\/span> in<\/span> private<\/span> pharmacopoeia<\/span> articles<\/span> for<\/span> the<\/span> tested<\/span> ointment.<\/span> Standardization<\/span> of<\/span> ointments<\/span> and<\/span> therapeutic<\/span> creams<\/span> according<\/span> to<\/span> the<\/span> qualitative<\/span> and<\/span> quantitative<\/span> content<\/span> of<\/span> medicinal<\/span> substances<\/span> or<\/span> the<\/span> determination<\/span> of<\/span> authenticity<\/span> is<\/span> carried<\/span> out<\/span> visually<\/span> by<\/span> appearance<\/span> and<\/span> by<\/span> organoleptic<\/span> signs,<\/span> as<\/span> well<\/span> as<\/span> by<\/span> conducting<\/span> qualitative<\/span> reactions<\/span> to<\/span> medicinal<\/span> substances<\/span> included<\/span> in<\/span> their<\/span> composition.<\/span> The<\/span> permissible<\/span> deviation<\/span> in<\/span> the<\/span> content<\/span> of<\/span> the<\/span> medicinal<\/span> substance<\/span> in<\/span> ointments,<\/span> liniments,<\/span> pastes<\/span> and<\/span> therapeutic<\/span> creams<\/span> should<\/span> not<\/span> exceed<\/span> \u00b1<\/span> 5%.<\/span> If<\/span> necessary,<\/span> determine<\/span> the<\/span> authenticity<\/span> of<\/span> the<\/span> excipients<\/span> and<\/span> the<\/span> type<\/span> of<\/span> base.<\/span> Ointments<\/span> should<\/span> be<\/span> homogeneous.<\/span> The<\/span> uniformity<\/span> of<\/span> ointments<\/span> is<\/span> determined<\/span> taking<\/span> into<\/span> account<\/span> the<\/span> properties<\/span> of<\/span> a<\/span> particular<\/span> drug<\/span> in<\/span> appearance<\/span> or<\/span> according<\/span> to<\/span> the<\/span> following<\/span> method.<\/span> Take<\/span> 4<\/span> samples<\/span> of<\/span> the<\/span> drug<\/span> of<\/span> 20-30<\/span> mg<\/span> each,<\/span> place<\/span> 2<\/span> samples<\/span> on<\/span> a<\/span> slide,<\/span> cover<\/span> with<\/span> a<\/span> second<\/span> slide<\/span> and<\/span> press<\/span> tightly<\/span> until<\/span> spots<\/span> with<\/span> a<\/span> diameter<\/span> of<\/span> about<\/span> 2<\/span> cm<\/span> are<\/span> formed.<\/span> When<\/span> examining<\/span> the<\/span> samples<\/span> obtained<\/span> with<\/span> the<\/span> naked<\/span> eye<\/span> (at<\/span> a<\/span> distance<\/span> of<\/span> about<\/span> 30<\/span> cm<\/span> from<\/span> the<\/span> eyes),<\/span> all<\/span> four<\/span> samples<\/span> should<\/span> not<\/span> contain<\/span> inclusions<\/span> and<\/span> (if<\/span> there<\/span> are<\/span> no<\/span> other<\/span> indications<\/span> in<\/span> the<\/span> private<\/span> article)<\/span> signs<\/span> of<\/span> physical<\/span> instability:<\/span> aggregation<\/span> and<\/span> coalescence<\/span> of<\/span> particles,<\/span> coagulations,<\/span> stratification.<\/span> If<\/span> visible<\/span> extraneous<\/span> inclusions<\/span> are<\/span> present<\/span> in<\/span> one<\/span> of<\/span> the<\/span> samples,<\/span> then<\/span> the<\/span> determination<\/span> is<\/span> carried<\/span> out<\/span> additionally<\/span> on<\/span> eight<\/span> more<\/span> samples.<\/span> At<\/span> the<\/span> same<\/span> time,<\/span> the<\/span> presence<\/span> of<\/span> extraneous<\/span> inclusions<\/span> is<\/span> not<\/span> allowed<\/span> in<\/span> all<\/span> additional<\/span> samples.<\/span> The<\/span> degree<\/span> of<\/span> dispersion<\/span> of<\/span> the<\/span> particles<\/span> of<\/span> ointments<\/span> and<\/span> creams<\/span> is<\/span> determined<\/span> using<\/span> an<\/span> electron<\/span> microscope<\/span> with<\/span> an<\/span> ocular<\/span> micrometer.<\/span> For<\/span> suspension<\/span> ointments,<\/span> the<\/span> dispersion<\/span> of<\/span> solid<\/span> particles<\/span> is<\/span> determined<\/span> according<\/span> to<\/span> the<\/span> methodology<\/span> of<\/span> the<\/span> State<\/span> Pharmacopoeia.<\/span> The<\/span> norms<\/span> of<\/span> the<\/span> degree<\/span> of<\/span> particle<\/span> dispersion<\/span> are<\/span> individual<\/span> for<\/span> each<\/span> ointment<\/span> and<\/span> should<\/span> be<\/span> indicated<\/span> in<\/span> the<\/span> private<\/span> articles<\/span> of<\/span> the<\/span> pharmacopoeia.<\/span><\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"
Intra-shop control of ointments is carried out at almost every stage of production and especially before packing the drug. The final conclusion on all indicators of the quality of finished products is given by the quality control department of the plant. In the conditions of industrial production, the test is carried out in accordance with…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false,"two_page_speed":[]},"categories":[3181,2175,2188],"tags":[2380,2381,2372,2376,2373,2197,2378,2374,156,193,2196,43,2193,2195,2377,2370,2191,2379,155,194,2375,2198,2192,2371,2194],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Author Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"HEPARIN OINTMENT<\/a> PHARMACEUTICAL PRODUCTION TECHNOLOGIES<\/a> PRODUCTION OF CREAMS AND OINTMENTS EQUIPMENT<\/a>","rttpg_excerpt":"Intra-shop control of ointments is carried out at almost every stage of production and especially before packing the drug. The final conclusion on all indicators of the quality of finished products is given by the quality control department of the plant. In the conditions of industrial production, the test is carried out in accordance with...","_links":{"self":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/58578"}],"collection":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/comments?post=58578"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/58578\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/media?parent=58578"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/categories?post=58578"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/tags?post=58578"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}