{"id":58218,"date":"2024-01-16T12:55:10","date_gmt":"1970-01-01T00:00:00","guid":{"rendered":"https:\/\/minipress.ru\/katalog\/?p=58218"},"modified":"2024-01-16T12:55:10","modified_gmt":"1970-01-01T00:00:00","slug":"coating-methods-and-equipment","status":"publish","type":"post","link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/pharmaceutical-production-technologies\/coating-methods-and-equipment\/","title":{"rendered":"Coating methods and equipment"},"content":{"rendered":"
[vc_row][vc_column][vc_column_text]<\/span>In<\/span> modern<\/span> pharmaceutical<\/span> production,<\/span> the<\/span> following<\/span> methods<\/span> of<\/span> applying<\/span> film<\/span> coatings<\/span> are<\/span> used.<\/span>Coating<\/span> in<\/span> drums;<\/span> coating<\/span> in<\/span> a<\/span> fluidized<\/span> bed<\/span> (spraying<\/span> from<\/span> above,<\/span> spraying<\/span> from<\/span> below,<\/span> coating<\/span> tangentially);<\/span> technology<\/span> of<\/span> jet<\/span> fluidization.<\/span> Coating<\/span> in<\/span> drums<\/span> has<\/span> already<\/span> been<\/span> discussed<\/span> in<\/span> the<\/span> section<\/span> \"Methods<\/span> and<\/span> equipment<\/span> for<\/span> coating\".<\/span>The<\/span> technological<\/span> parameters<\/span> of<\/span> the<\/span> film<\/span> coating<\/span> process<\/span> are:<\/span> temperature,<\/span> quantity<\/span> and<\/span> humidity<\/span> of<\/span> incoming<\/span> and<\/span> outgoing<\/span> air,<\/span> spray<\/span> rate<\/span> and<\/span> pressure<\/span> from<\/span> the<\/span> nozzle,<\/span> layer<\/span> temperature.<\/span> At<\/span> the<\/span> same<\/span> time,<\/span> the<\/span> technological<\/span> parameters<\/span> can<\/span> be<\/span> adjustable<\/span> (temperature<\/span> and<\/span> amount<\/span> of<\/span> incoming<\/span> air),<\/span> unregulated<\/span> (humidity<\/span> at<\/span> the<\/span> inlet)<\/span> and<\/span> fixed<\/span> (spray<\/span> rate<\/span> and<\/span> duration<\/span> of<\/span> the<\/span> process.<\/span> DIOSNA<\/span> has<\/span> developed<\/span> a<\/span> vertical<\/span> centrifugal<\/span> coater<\/span> VCC<\/span> (from<\/span> the<\/span> English<\/span> coater<\/span> \u2014<\/span> coating<\/span> plant).<\/span> Unlike<\/span> conventional<\/span> drum-type<\/span> coating<\/span> systems,<\/span> the<\/span> VCC<\/span> coater<\/span> has<\/span> two<\/span> cones<\/span> mounted<\/span> vertically<\/span> and<\/span> positioned<\/span> one<\/span> above<\/span> the<\/span> other.<\/span> The<\/span> lower<\/span> cone<\/span> rotates<\/span> and<\/span> the<\/span> tablets<\/span> to<\/span> be<\/span> coated<\/span> rise<\/span> smoothly<\/span> to<\/span> the<\/span> lower<\/span> edge<\/span> of<\/span> the<\/span> upper<\/span> cone<\/span> under<\/span> the<\/span> action<\/span> of<\/span> centrifugal<\/span> force.<\/span> Here<\/span> the<\/span> tablets<\/span> begin<\/span> to<\/span> lose<\/span> speed<\/span> and<\/span> return<\/span> to<\/span> the<\/span> lower<\/span> point<\/span> of<\/span> the<\/span> rotating<\/span> cone.<\/span> Along<\/span> the<\/span> way,<\/span> the<\/span> tablets<\/span> pass<\/span> through<\/span> the<\/span> working<\/span> area<\/span> of<\/span> the<\/span> nozzle<\/span> with<\/span> a<\/span> 360\u00b0<\/span> spray<\/span> angle,<\/span> where<\/span> they<\/span> are<\/span> coated.<\/span> At<\/span> the<\/span> same<\/span> time,<\/span> all<\/span> tablets<\/span> passing<\/span> through<\/span> this<\/span> zone<\/span> are<\/span> covered.<\/span> The<\/span> circulating<\/span> movement<\/span> of<\/span> the<\/span> tablets<\/span> is<\/span> repeated.<\/span> This<\/span> unique<\/span> product<\/span> flow<\/span> eliminates<\/span> the<\/span> formation<\/span> of<\/span> neutral<\/span> or<\/span> dead<\/span> zones,<\/span> the<\/span> presence<\/span> of<\/span> which<\/span> is<\/span> the<\/span> main<\/span> disadvantage<\/span> of<\/span> a<\/span> conventional<\/span> drum<\/span> set.<\/span>During<\/span> circulation,<\/span> the<\/span> tablets<\/span> are<\/span> intensively<\/span> and<\/span> evenly<\/span> dried<\/span> (both<\/span> during<\/span> centrifugal<\/span> upward<\/span> movement<\/span> and<\/span> when<\/span> returning<\/span> to<\/span> the<\/span> lower<\/span> point<\/span> of<\/span> the<\/span> working<\/span> chamber).<\/span> Drying<\/span> of<\/span> tablets<\/span> begins<\/span> immediately<\/span> after<\/span> passing<\/span> through<\/span> the<\/span> spray<\/span> zone<\/span> by<\/span> the<\/span> air<\/span> flow<\/span> coming<\/span> from<\/span> below<\/span> through<\/span> the<\/span> perforated<\/span> bottom<\/span> of<\/span> the<\/span> chamber.<\/span> Due<\/span> to<\/span> the<\/span> optimal<\/span> flow<\/span> of<\/span> tablets<\/span> and<\/span> the<\/span> fact<\/span> that<\/span> the<\/span> coating<\/span> material<\/span> is<\/span> applied<\/span> frequently<\/span> and<\/span> in<\/span> small<\/span> portions,<\/span> the<\/span> drying<\/span> time<\/span> in<\/span> the<\/span> VCC<\/span> coater<\/span> is<\/span> small<\/span> and<\/span> the<\/span> coating<\/span> process<\/span> time<\/span> can<\/span> be<\/span> reduced<\/span> by<\/span> 50%<\/span> (or<\/span> even<\/span> more),<\/span> both<\/span> with<\/span> organic-based<\/span> coatings<\/span> and<\/span> with<\/span> water-based<\/span> coatings.<\/span> As<\/span> a<\/span> result,<\/span> tablets<\/span> with<\/span> a<\/span> uniform<\/span> coating<\/span> are<\/span> obtained<\/span> in<\/span> a<\/span> short<\/span> period<\/span> of<\/span> time.<\/span> Thanks<\/span> to<\/span> the<\/span> smooth<\/span> controlled<\/span> flow<\/span> of<\/span> the<\/span> product,<\/span> even<\/span> with<\/span> difficult\u2014to-process<\/span> products<\/span> (such<\/span> as<\/span> loose<\/span> or<\/span> delicate<\/span> material<\/span> or<\/span> a<\/span> product<\/span> of<\/span> complex<\/span> shape),<\/span> the<\/span> coating<\/span> technology<\/span> in<\/span> the<\/span> VCC<\/span> coater<\/span> gives<\/span> good<\/span> results.<\/span> As<\/span> a<\/span> result,<\/span> all<\/span> tablets<\/span> coated<\/span> in<\/span> a<\/span> vertical<\/span> centrifugal<\/span> VCC<\/span> coater<\/span> are<\/span> uniform<\/span> in<\/span> color,<\/span> glossy,<\/span> with<\/span> a<\/span> beautiful<\/span> appearance.<\/span> The<\/span> application<\/span> of<\/span> a<\/span> film<\/span> coating<\/span> in<\/span> fluidized<\/span> bed<\/span> apparatuses<\/span> is<\/span> a<\/span> process<\/span> that<\/span> consists<\/span> of<\/span> spraying<\/span> a<\/span> thin<\/span> homogeneous<\/span> film<\/span> on<\/span> the<\/span> surface<\/span> of<\/span> tablets,<\/span> pellets,<\/span> granules<\/span> in<\/span> a<\/span> fluidized<\/span> state.<\/span>[\/vc_column_text][\/vc_column][\/vc_row]<\/span><\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][vc_column_text]In modern pharmaceutical production, the following methods of applying film coatings are used.Coating in drums; coating in a fluidized bed (spraying from above, spraying from below, coating tangentially); technology of jet fluidization. Coating in drums has already been discussed in the section “Methods and equipment for coating”.The technological parameters of the film coating process are:…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false,"two_page_speed":[]},"categories":[2185,2175],"tags":[2380,75,77,76,2381,2372,2376,2373,2378,2374,78,43,2186,2377,2370,2379,2189,2190,63,95,2375,2371,212],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Author Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"FILM-COATING OF TABLETS<\/a> PHARMACEUTICAL PRODUCTION TECHNOLOGIES<\/a>","rttpg_excerpt":"[vc_row][vc_column][vc_column_text]In modern pharmaceutical production, the following methods of applying film coatings are used.Coating in drums; coating in a fluidized bed (spraying from above, spraying from below, coating tangentially); technology of jet fluidization. Coating in drums has already been discussed in the section \"Methods and equipment for coating\".The technological parameters of the film coating process are:...","_links":{"self":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/58218"}],"collection":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/comments?post=58218"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/58218\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/media?parent=58218"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/categories?post=58218"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/tags?post=58218"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}