{"id":58068,"date":"2024-01-16T15:23:28","date_gmt":"1970-01-01T00:00:00","guid":{"rendered":"https:\/\/minipress.ru\/katalog\/?p=58068"},"modified":"2024-01-16T15:23:28","modified_gmt":"1970-01-01T00:00:00","slug":"filling-technologies-for-hard-gelatin-capsules","status":"publish","type":"post","link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/pharmaceutical-production-technologies\/filling-technologies-for-hard-gelatin-capsules\/","title":{"rendered":"Filling technologies for hard gelatin capsules"},"content":{"rendered":"
Over<\/span> the<\/span> past<\/span> few<\/span> years,<\/span> capsule<\/span> filling<\/span> technology<\/span> has<\/span> undergone<\/span> significant<\/span> changes<\/span> in<\/span> the<\/span> pharmaceutical<\/span> industry.<\/span> The<\/span> basic<\/span> idea<\/span> of<\/span> capsule<\/span> filling<\/span> has<\/span> expanded<\/span> from<\/span> filling<\/span> with<\/span> solid<\/span> forms<\/span> to<\/span> filling<\/span> with<\/span> liquid<\/span> forms.<\/span> Until<\/span> recently,<\/span> soft<\/span> gelatin<\/span> capsules<\/span> were<\/span> the<\/span> only<\/span> alternative<\/span> for<\/span> encapsulating<\/span> difficult-to-dissolve<\/span> dosage<\/span> forms.<\/span> Today,<\/span> new<\/span> technologies<\/span> have<\/span> been<\/span> developed<\/span> for<\/span> filling<\/span> solid<\/span> gelatin<\/span> capsules<\/span> with<\/span> liquid<\/span> medicinal<\/span> substances<\/span> and<\/span> sealing<\/span> them<\/span> as<\/span> an<\/span> alternative<\/span> replacement<\/span> for<\/span> soft<\/span> gelatin<\/span> capsules.<\/span> This<\/span> simplifies<\/span> the<\/span> process<\/span> of<\/span> filling<\/span> capsules<\/span> and<\/span> helps<\/span> to<\/span> avoid<\/span> many<\/span> problems<\/span> associated<\/span> with<\/span> filling<\/span> soft<\/span> gelatin<\/span> capsules.<\/span> The<\/span> fundamental<\/span> differences<\/span> between<\/span> the<\/span> filling<\/span> of<\/span> hard<\/span> and<\/span> soft<\/span> gelatin<\/span> capsules<\/span> are<\/span> as<\/span> follows.<\/span> Moisture<\/span> content.<\/span> In<\/span> solid<\/span> gelatin<\/span> capsules,<\/span> the<\/span> moisture<\/span> content<\/span> can<\/span> reach<\/span> up<\/span> to<\/span> 50%.<\/span> Soft<\/span> gelatin<\/span> capsules<\/span> consist<\/span> of<\/span> a<\/span> plasticizer<\/span> that<\/span> retains<\/span> up<\/span> to<\/span> 30%<\/span> moisture.<\/span> As<\/span> a<\/span> result,<\/span> the<\/span> moisture<\/span> absorption<\/span> capacity<\/span> of<\/span> soft<\/span> gelatin<\/span> capsules<\/span> is<\/span> much<\/span> higher<\/span> than<\/span> that<\/span> of<\/span> solid<\/span> ones.<\/span> Another<\/span> property<\/span> of<\/span> the<\/span> plasticizer<\/span> is<\/span> the<\/span> migration<\/span> of<\/span> the<\/span> filler<\/span> into<\/span> the<\/span> walls<\/span> of<\/span> a<\/span> soft<\/span> gelatin<\/span> capsule,<\/span> which<\/span> can<\/span> lead<\/span> to<\/span> a<\/span> change<\/span> in<\/span> the<\/span> formula<\/span> of<\/span> the<\/span> medicinal<\/span> substance.<\/span> Oxygen<\/span> transmission<\/span> level.<\/span> In<\/span> the<\/span> film<\/span> of<\/span> soft<\/span> gelatin<\/span> capsules,<\/span> the<\/span> level<\/span> of<\/span> oxygen<\/span> transfer<\/span> increases<\/span> with<\/span> an<\/span> increase<\/span> in<\/span> the<\/span> level<\/span> of<\/span> glycerin<\/span> and<\/span> moisture.<\/span> Since<\/span> the<\/span> content<\/span> of<\/span> plasticizer<\/span> in<\/span> hard<\/span> gelatin<\/span> capsules<\/span> is<\/span> minimal,<\/span> the<\/span> permeability<\/span> of<\/span> their<\/span> walls<\/span> is<\/span> lower<\/span> than<\/span> that<\/span> of<\/span> soft<\/span> gelatin<\/span> capsules.<\/span> As<\/span> a<\/span> result,<\/span> solid<\/span> gelatin<\/span> capsules<\/span> can<\/span> be<\/span> filled<\/span> with<\/span> medicinal<\/span> substances<\/span> with<\/span> high<\/span> odor<\/span> permeability,<\/span> such<\/span> as<\/span> fish<\/span> oil,<\/span> valerian<\/span> and<\/span> garlic<\/span> oil.<\/span> In<\/span> addition,<\/span> the<\/span> aesthetic<\/span> appearance<\/span> of<\/span> the<\/span> dosage<\/span> form<\/span> worries<\/span> many<\/span> manufacturers.<\/span> This<\/span> problem<\/span> is<\/span> easier<\/span> to<\/span> solve<\/span> when<\/span> filling<\/span> solid<\/span> gelatin<\/span> capsules<\/span> with<\/span> liquids<\/span> and<\/span> sealing<\/span> them,<\/span> since<\/span> there<\/span> is<\/span> a<\/span> whole<\/span> color<\/span> scheme<\/span> to<\/span> improve<\/span> their<\/span> appearance.<\/span> Biological<\/span> activity.<\/span> The<\/span> biological<\/span> activity<\/span> of<\/span> difficult-to-dissolve<\/span> medicinal<\/span> substances<\/span> can<\/span> significantly<\/span> increase<\/span> if<\/span> these<\/span> substances<\/span> are<\/span> \"packaged\"<\/span> in<\/span> solid<\/span> gelatin<\/span> capsules,<\/span> which<\/span> makes<\/span> their<\/span> use<\/span> possible<\/span> and<\/span> increases<\/span> the<\/span> effectiveness<\/span> of<\/span> the<\/span> drug.<\/span> The<\/span> dissolution<\/span> temperature.<\/span> Materials<\/span> with<\/span> a<\/span> low<\/span> dissolution<\/span> temperature<\/span> (or<\/span> those<\/span> materials<\/span> that<\/span> become<\/span> liquid<\/span> at<\/span> room<\/span> temperature)<\/span> are<\/span> difficult<\/span> to<\/span> produce<\/span> in<\/span> powder<\/span> form.<\/span><\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"
Over the past few years, capsule filling technology has undergone significant changes in the pharmaceutical industry. The basic idea of capsule filling has expanded from filling with solid forms to filling with liquid forms. Until recently, soft gelatin capsules were the only alternative for encapsulating difficult-to-dissolve dosage forms. Today, new technologies have been developed for…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false,"two_page_speed":[]},"categories":[2175,2177],"tags":[2380,2381,2372,2376,2373,2378,2374,87,85,86,84,141,81,2377,2370,2379,39,142,2375,82,2371,83],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Author Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/pharmaceutical-equipment\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"PHARMACEUTICAL PRODUCTION TECHNOLOGIES<\/a> PRODUCTION OF GELATIN CAPSULES FOR MEDICINES<\/a>","rttpg_excerpt":"Over the past few years, capsule filling technology has undergone significant changes in the pharmaceutical industry. The basic idea of capsule filling has expanded from filling with solid forms to filling with liquid forms. Until recently, soft gelatin capsules were the only alternative for encapsulating difficult-to-dissolve dosage forms. Today, new technologies have been developed for...","_links":{"self":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/58068"}],"collection":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/comments?post=58068"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/posts\/58068\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/media?parent=58068"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/categories?post=58068"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/pharmaceutical-equipment\/wp-json\/wp\/v2\/tags?post=58068"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}