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Granulation of a mixture of drug and excipients using part of a binder solution, followed by adding the remaining part of the dry binder to the finished granular material. There are a number of factors that determine which method should be used. For many formulations, using Method 1 produces tablets with faster disintegration times and faster release of the drug than using Method 2. In many cases, Method 1 produces slightly harder tablets than Method 2. Method 3 is used when Method 1 cannot be used (for example, when the tableted mixture cannot absorb the required amount of liquid). In case of difficulties related to the decay time, it is recommended to use method 4.
Specifications
In order for the powder to granulate, it must be moistened to a certain extent. For this, powders are mixed with granulating liquids. The optimal amount of humidifier is determined experimentally (based on the physicochemical properties of the powders) and is indicated in the regulations. If there is not enough humidifier, then the granules will crumble after drying, if there is a lot, the mass will be viscous, sticky and poorly granulated. A mass with optimal humidity is a moist, dense mixture that does not stick to the hand, but crumbles into separate lumps when squeezed. Binders are necessary in order to bind the powder particles and prevent surface disruption of the finished tablets, i.e. increase tablet strength and resistance to destruction. The binder (granulating) liquid enters the solid particles of the powder, wetting it and forming liquid "bridges".
Tips for our customers
When the mixture of active and auxiliary substances with granulating liquid is dehydrated, the binder liquid "bridges" gradually turn into solid "bridges" and as a result agglomerates (final granules having the structure of a "snowball") are formed. The connection of particles occurs due to molecular, electrostatic and capillary forces. The formation of "bridges" can occur due to the chemical reaction. Wet granulation remains the most widely used method for the manufacture of mixtures for the production of tablets. There are at least four different options for the method: Granulation of a mixture of drug and excipients using a binder solution. Granulation of a mixture of drug and excipients with a binder and a pure solvent.
Granulation of a mixture of drug and excipients and part of a binder using a solution of the remaining part of the binder.
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