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Wet granulation of powders

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980100
  • Granulation for tablets
  • Vegetable pills
  • Powder Granulation Equipment
  • Powder Granulation Press
  • Granulation for tablets
  • Vegetable pills
  • Powder Granulation Equipment
  • Powder Granulation Press

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Wet granulation of powders

Wet granulation is applied to powders having poor flowability and insufficient adhesion between particles. In both cases, binder solutions are added to the mass to improve adhesion between particles. Granulation, or wiping of a wet mass, is carried out with the aim of compacting the powder and obtaining uniform grains - granules with good flowability. Wet granulation includes successive stages: grinding the substances into a fine powder and mixing the dry medicinal substance with excipients; mixing powders with granulating liquids; granulation; drying wet granules; dusting of dry granules. Grinding and mixing are carried out in mills and mixers of various designs presented earlier. The resulting powder is sieved through sieves.

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  • Updated: 08/10/2019
  • Pharmaceutical equipment in stock and on order
  • Warranty: 1 year for wet powder granulation equipment

Model: Wet granulation of powders

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What is included in the price

  1. Phased expert assessment your problem and a detailed discussion of solutions in 24 hours.
  2. Company selection manufacturer and conversation with the selected supplier.
  3. Selection, optimal for the client, payment scheme and delivery time.
  4. Receiving and checking equipment before sending with a video report.
  5. Consultation from our specialist with 17 years of experience  throughout the life of the equipment.

If you did not find the necessary equipment in our catalog, then call +74953643808 and we will certainly offer you what you were looking for, or we will pick up similar equipment that is suitable not only for technical characteristics, but also for price.
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Granulation of a mixture of drug and excipients using part of a binder solution, followed by adding the remaining part of the dry binder to the finished granular material. There are a number of factors that determine which method should be used. For many formulations, using Method 1 produces tablets with faster disintegration times and faster release of the drug than using Method 2. In many cases, Method 1 produces slightly harder tablets than Method 2. Method 3 is used when Method 1 cannot be used (for example, when the tableted mixture cannot absorb the required amount of liquid). In case of difficulties related to the decay time, it is recommended to use method 4.

Specifications

In order for the powder to granulate, it must be moistened to a certain extent. For this, powders are mixed with granulating liquids. The optimal amount of humidifier is determined experimentally (based on the physicochemical properties of the powders) and is indicated in the regulations. If there is not enough humidifier, then the granules will crumble after drying, if there is a lot, the mass will be viscous, sticky and poorly granulated. A mass with optimal humidity is a moist, dense mixture that does not stick to the hand, but crumbles into separate lumps when squeezed. Binders are necessary in order to bind the powder particles and prevent surface disruption of the finished tablets, i.e. increase tablet strength and resistance to destruction. The binder (granulating) liquid enters the solid particles of the powder, wetting it and forming liquid "bridges".

Tips for our customers

When the mixture of active and auxiliary substances with granulating liquid is dehydrated, the binder liquid "bridges" gradually turn into solid "bridges" and as a result agglomerates (final granules having the structure of a "snowball") are formed. The connection of particles occurs due to molecular, electrostatic and capillary forces. The formation of "bridges" can occur due to the chemical reaction. Wet granulation remains the most widely used method for the manufacture of mixtures for the production of tablets. There are at least four different options for the method: Granulation of a mixture of drug and excipients using a binder solution. Granulation of a mixture of drug and excipients with a binder and a pure solvent.
Granulation of a mixture of drug and excipients and part of a binder using a solution of the remaining part of the binder.

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