The German-Swiss company FrymaKoruma, a member of the Romaco group of companies, is well known in the global pharmaceutical equipment market. In Russia, the equipment of this company is also widely represented at many enterprises. In particular, at one of the leading Russian pharmaceutical companies of Akrikhin OJSC, the production of ointments and creams is carried out at the FrymaKoruma Disho installation. Vacuum-production plant for liquid and pasty products FrymaKoruma MaxxD, which has the same operating principle as the Disho plant, but is a more modern development of the company. FrymaKoruma MaxxD is a modular system for the production of emulsions and suspensions with a wide range of viscosities. The main advantages of the installation are high production efficiency, reduced operating costs and increased productivity. The MaxxD installation is universal, as it is capable of producing a large name of products in different volumes and using various technologies. Improved production technology provides shortened production cycles, flexible ...
The diphilic bases have a soft consistency and are easily distributed on the surface of the skin and mucous membranes. The diphilic bases are divided into two groups - absorption and emulsion. Absorption bases are hydrophobic. These are anhydrous emulsifier (SAS) hydrophobic compositions with the ability to incorporate the aqueous phase to form an oil-water emulsion system. Most often they contain mixtures of petroleum jelly, petroleum jelly, ceresin and other hydrocarbons with emulsifiers. Surfactants, which are part of the absorption bases, usually contribute to enhancing the therapeutic activity of ointments. Absorbable diphilic bases can be divided into two groups: diphilic bases, consisting of hydrocarbons and emulsifiers (surfactants) of the water-oil type (petrolatum and lanolin or wool wax alcohols), which can contain significant amounts of water or aqueous solutions to form an emulsion type water — oil; Diphilic bases, which are emulsions of the type water-oil ...
Hydrophobic, or lipophilic, bases are chemically heterogeneous substances and their mixtures having pronounced hydrophobicity. This group includes: fatty bases; hydrocarbon bases; silicone bases. Fat bases include animal, vegetable and hydrogenated fats, as well as waxes. Animal fats, by their chemical nature, are triglycerides of higher fatty acids. By properties, they are close to fatty secretions of the skin. In addition, fats contain unsaponifiable components, among which cholesterol predominates. The most common animal fat is Adeps suillus seu Axungiaporcina (depurata). This is a mixture of stearic, palmitic, oleic and linoleic acid triglycerides. Pork fat also contains a small amount of cholesterol. It is a white mass almost odorless with a melting point of 34-36 "C. Ointments on pork fat are well absorbed by the skin, do not irritate and are easily removed with soapy water ....
The next stage in the production of ointments is homogenization. This is a specific stage, since with stirring the desired degree of dispersion of medicinal substances is not always achieved. Various equipment is used for homogenization, such as roller or disk maser, millstones and colloidal mills, as well as homogenizing-dispersing agents. Roll mazeterki have two or three rolls with a smooth surface, rotating towards each other at different speeds, ensuring the transition of the ointment from the shaft to the shaft and increasing friction between them. Rolls are made of porcelain, basalt or metal. To maintain the optimum temperature of the ointment entering the rolls, they are hollow, so that if necessary, water can be supplied inside. The maser is a system of three rolls in contact with each other, the axes of which lie in the same plane. Two extreme rolls are pressed to the middle springs. The gap between the middle and extreme rolls is adjustable. Ointments ...
Hydrophilic bases are mixed with water in any ratio. The following ointment bases are hydrophilic: solutions and gels of polysaccharides; solutions and gels of natural and synthetic polymers; phytosterol gels; clay mineral gels; solutions and gels of proteins. The advantages of hydrophilic bases are: the possibility of introducing a significant amount of aqueous solutions of medicinal substances; ease of release of drugs, which ensures their high bioavailability; good absorption in the skin, the bases are easily removed from the place of application and washed off with water from the skin. The disadvantages of hydrophilic bases include microbial contamination and rapid drying (this property does not apply to polyethylene oxides), as well as incompatibility with a number of medicinal substances and susceptibility to syneresis - a phenomenon in which the liquid phase is released. Polysaccharide solutions and gels as the basis for ointments. Recently, in our country and abroad for the preparation of the bas ...
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