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Basic tablet requirements

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Catalog / Pharmaceutical Technology / Tablet technology / Basic tablet requirements

Basic tablet requirements

The following requirements are made for tablets: dosing accuracy - uniformity (uniformity) of the distribution of the active substance in the tablet, the correct weight of both the tablet itself and the medicinal substances included in its composition;
mechanical strength - hardness, brittleness, brittleness - characterize the quality of the tablets; tablets should be strong enough to remain intact under mechanical stress during packaging, transportation and storage;
disintegration or solubility - the ability to disintegrate or dissolve within the time period established by the relevant scientific and technical documentation (NTD) for certain types of tablets. The accuracy of the dosage depends on the uniformity of the tableted mass, which is ensured by thoroughly mixing the medicinal and auxiliary substances and their uniform distribution in the total mass. Dosing accuracy also depends on the speed and reliability of filling the matrix slot of the tablet machine. If in a short time the funnel is above the matrix hole, less material is poured out than the matrix nest can accept, the mass of the obtained tablets will be insufficient. The required filling speed of the matrix nest depends on the shape of the funnel, the angle of the ramp and whether the particles of the tableted mass have sufficient slip. Often, the friction forces between individual particles, due to the roughness of their surface, are so large that the matrix nest is not completely filled or is not filled at all due to the retention of the powder in the funnel.

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  • Updated: 08/10/2019
  • Pharmaceutical equipment in stock and on order
  • Warranty: 1 year for tablet manufacturing equipment

Model: The main requirements for tablets.

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In such cases, it is necessary to add substances with a higher adhesion force (starch, gelatin solutions, etc.) and again it is necessary to resort to granulation in order to introduce binders into the tableted mass that increase the plasticity of the drug substances; this manifests a property called adhesion, which causes the particles to adhere to each other.
Disintegration. The tablet should have the necessary disintegration with sufficient mechanical strength. Too high strength of the tablet affects its disintegration and release of the drug - the disintegration time increases, which negatively affects the quality of the tablet. Disintegration depends on a number of reasons: on the amount of binders: tablets should contain such an amount that is necessary to achieve the required strength; from pressing pressure: excessive pressure worsens the disintegration of the tablet; on the quality of disintegrants that contribute to the disintegration of tablets; from the properties of the substances included in the tablet, from their ability to dissolve in water, wet with it, swell; tablets with readily soluble substances will disintegrate more quickly and less loosening substances will be required.
The mass subjected to tableting should have a combination of properties that ensure the fulfillment of the above requirements: dosing accuracy, mechanical strength and disintegration.

Specifications

In these cases, anti-friction substances are added to the material, which reduce friction between the particles due to giving them a smooth surface. Usually, fine powders possess poor adhesion, which tend to adhere to the surface of the funnel; therefore, it is necessary to artificially increase the particle size to the optimum size by granulating the material.
Exfoliation causes a change in tablet weight. In some cases, delamination can be prevented by installing a small stirrer in the funnel, but a more radical measure is to level the particles by granulating the material. Speaking about the homogeneity of the material, they also mean its uniformity in the shape of the particles. Obviously, particles with different spatial shapes with approximately the same mass will be placed in a matrix slot with different compactness.
This fact will also cause fluctuations in the mass of tablets. Particle alignment is achieved by a granulation process. It should be noted that it is quite difficult to achieve uniformity of the granules, therefore, by varying the ratio of granulate fractions empirically, it is possible to establish the optimal composition that meets the best flowability and high quality tablets at a certain compression pressure.
Mechanical strength. Mechanical strength determines the interlocking of particles. At the beginning of the pressing process, the tableted mass becomes denser, closer approach of the particles occurs, and conditions are created for the manifestation of intermolecular and electrostatic forces.

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The forces of intermolecular interaction are manifested when the particles approach each other at a distance of 10 ″ 6-10 ″ 7 cm. The process of pressing the tableted mass can be divided into three stages. The mechanical strength depends on the pressure during the pressing process and it is important to monitor how the pressure will increase during pressing. In impact tablet machines (eccentric), the pressure rises sharply, as a result of which the surface of the tablet under the impact of punches is very hot (mechanical energy goes into heat) and the substances melt, forming a continuous cementing layer.
In rotary tablet machines, the pressure rises gradually, which gives better results, since it provides a longer effect of pressure on the tablet mass. The longer the exposure, the more completely air will be removed from the tableted mass, which, after depressurization, expanding, can have a destructive effect on the tablets. In addition, the heating of the tablet at the surface is significantly reduced, which eliminates the harmful effects of elevated temperature on the substances that make up the tablet.
The use of high pressure during pressing can adversely affect the quality of tablets and contribute to the wear of tablet machines. High pressure can be compensated by the addition of substances having a large dipole moment and ensuring the adhesion of particles at relatively low pressures.
Water, possessing a sufficient dipole moment, is a "bridge" between these particles. Water will interfere with the binding of particles of insoluble and insoluble drugs.

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