{"id":59389,"date":"2024-01-16T13:36:03","date_gmt":"2024-01-16T10:36:03","guid":{"rendered":"https:\/\/minipress.ru\/katalog\/?p=59389"},"modified":"2024-03-29T14:54:06","modified_gmt":"2024-03-29T11:54:06","slug":"bases-para-supositorios-y-sus-requisitos","status":"publish","type":"post","link":"https:\/\/minipress.ru\/farmaceutico-equipos\/tecnologias-de-produccion-farmaceutica\/bases-para-supositorios-y-sus-requisitos\/","title":{"rendered":"Bases para supositorios y sus requisitos"},"content":{"rendered":"
[vc_row][vc_column][vc_column_text]<\/span>\n\nFrom<\/span> a<\/span> physico-chemical<\/span> point<\/span> of<\/span> view,<\/span> suppositories<\/span> are<\/span> considered<\/span> as<\/span> dispersed<\/span> systems<\/span> consisting<\/span> of<\/span> a<\/span> dispersion<\/span> medium,<\/span> represented<\/span> by<\/span> the<\/span> basis<\/span> of<\/span> the<\/span> Dispersed<\/span> phase,<\/span> in<\/span> the<\/span> role<\/span> of<\/span> which<\/span> medicinal<\/span> substances<\/span> act.<\/span> Depending<\/span> on<\/span> the<\/span> properties<\/span> of<\/span> medicinal<\/span> substances,<\/span> dispersed<\/span> systems<\/span> of<\/span> suppositories<\/span> can<\/span> be<\/span> either<\/span> homogeneous<\/span> or<\/span> heterogeneous.<\/span> Homogeneous<\/span> systems<\/span> are<\/span> formed<\/span> when<\/span> the<\/span> medicinal<\/span> substance<\/span> is<\/span> dissolved<\/span> in<\/span> the<\/span> base.<\/span> Heterogeneous<\/span> systems<\/span> are<\/span> formed<\/span> in<\/span> the<\/span> case<\/span> of<\/span> the<\/span> introduction<\/span> of<\/span> medecine<\/span> into<\/span> the<\/span> base<\/span> by<\/span> the<\/span> type<\/span> of<\/span> emulsion<\/span> or<\/span> suspension.<\/span> In<\/span> the<\/span> structure<\/span> of<\/span> suppositories,<\/span> there<\/span> are<\/span> basic<\/span> (medicinal<\/span> substances)<\/span> and<\/span> auxiliary<\/span> (carriers<\/span> or<\/span> base)<\/span> components.<\/span> There<\/span> are<\/span> a<\/span> number<\/span> of<\/span> requirements<\/span> for<\/span> suppository<\/span> bases:<\/span> the<\/span> bases<\/span> must<\/span> maintain<\/span> sufficient<\/span> hardness<\/span> at<\/span> room<\/span> temperature;<\/span> the<\/span> melting<\/span> (dissolution)<\/span> temperature<\/span> of<\/span> the<\/span> base<\/span> must<\/span> be<\/span> close<\/span> to<\/span> the<\/span> temperature<\/span> of<\/span> the<\/span> human<\/span> body;<\/span> the<\/span> bases<\/span> must<\/span> not<\/span> irritate<\/span> the<\/span> rectal<\/span> mucosa<\/span> or<\/span> cause<\/span> undesirable<\/span> phenomena,<\/span> i.e.<\/span> they<\/span> must<\/span> be<\/span> physiologically<\/span> indifferent;<\/span> suppository<\/span> bases<\/span> must<\/span> not<\/span> interfere<\/span> with<\/span> the<\/span> release<\/span> and<\/span> therapeutic<\/span> effect<\/span> of<\/span> the<\/span> medicinal<\/span> substance;<\/span> the<\/span> bases<\/span> should<\/span> not<\/span> interact<\/span> with<\/span> medicinal<\/span> substances<\/span> injected<\/span> into<\/span> the<\/span> suppository<\/span> mass.<\/span>\n\n[\/vc_column_text][\/vc_column][\/vc_row]<\/span><\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][vc_column_text] From a physico-chemical point of view, suppositories are considered as dispersed systems consisting of a dispersion medium, represented by the basis of the Dispersed phase, in the role of which medicinal substances act. Depending on the properties of medicinal substances, dispersed systems of suppositories can be either homogeneous or heterogeneous. Homogeneous systems are formed…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false,"footnotes":""},"categories":[2215,2175],"tags":[46,2380,2221,2381,43,2378,2374,2373,39,2222,2377,2370,140,2220,2224,2372,2379,2376,2223,2375,2371,2225,2191],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Autor Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/farmaceutico-equipos\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"FABRICACI\u00d3N DE SUPOSITORIOS EN PRODUCCI\u00d3N.<\/a> TECNOLOG\u00cdAS DE PRODUCCI\u00d3N FARMAC\u00c9UTICA<\/a>","rttpg_excerpt":"[vc_row][vc_column][vc_column_text] From a physico-chemical point of view, suppositories are considered as dispersed systems consisting of a dispersion medium, represented by the basis of the Dispersed phase, in the role of which medicinal substances act. Depending on the properties of medicinal substances, dispersed systems of suppositories can be either homogeneous or heterogeneous. Homogeneous systems are formed...","_links":{"self":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/posts\/59389"}],"collection":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/comments?post=59389"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/posts\/59389\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/media?parent=59389"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/categories?post=59389"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/tags?post=59389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}