{"id":58954,"date":"2024-01-16T13:21:07","date_gmt":"2024-01-16T10:21:07","guid":{"rendered":"https:\/\/minipress.ru\/katalog\/?p=58954"},"modified":"2024-04-01T12:25:50","modified_gmt":"2024-04-01T09:25:50","slug":"requisitos-basicos-para-tabletas","status":"publish","type":"post","link":"https:\/\/minipress.ru\/farmaceutico-equipos\/tecnologias-de-produccion-farmaceutica\/requisitos-basicos-para-tabletas\/","title":{"rendered":"Requisitos b\u00e1sicos para tabletas"},"content":{"rendered":"
[vc_row][vc_column][vc_column_text]<\/span>\r\n\r\nThe<\/span> following<\/span> requirements<\/span> are<\/span> imposed<\/span> on<\/span> tablets:<\/span> dosing<\/span> accuracy<\/span> \u2014<\/span> uniformity<\/span> (uniformity)<\/span> of<\/span> the<\/span> distribution<\/span> of<\/span> the<\/span> active<\/span> substance<\/span> in<\/span> the<\/span> tablet,<\/span> the<\/span> correctness<\/span> of<\/span> the<\/span> weight<\/span> of<\/span> both<\/span> the<\/span> tablet<\/span> itself<\/span> and<\/span> the<\/span> medicinal<\/span> substances<\/span> included<\/span> in<\/span> it;<\/span>\r\nmechanical<\/span> strength<\/span> \u2014<\/span> hardness,<\/span> brittleness,<\/span> fragility<\/span> \u2014<\/span> characterize<\/span> the<\/span> quality<\/span> of<\/span> tablets;<\/span> tablets<\/span> must<\/span> have<\/span> sufficient<\/span> strength<\/span> to<\/span> remain<\/span> intact<\/span> under<\/span> mechanical<\/span> influences<\/span> during<\/span> packaging,<\/span> transportation<\/span> and<\/span> storage;<\/span>\r\ndisintegration<\/span> or<\/span> solubility<\/span> \u2014<\/span> the<\/span> ability<\/span> to<\/span> disintegrate<\/span> or<\/span> dissolve<\/span> within<\/span> the<\/span> time<\/span> limits<\/span> established<\/span> by<\/span> the<\/span> relevant<\/span> scientific<\/span> and<\/span> technical<\/span> documentation<\/span> (NTD)<\/span> for<\/span> certain<\/span> types<\/span> of<\/span> tablets.<\/span> The<\/span> accuracy<\/span> of<\/span> dosing<\/span> depends<\/span> on<\/span> the<\/span> uniformity<\/span> of<\/span> the<\/span> tableted<\/span> mass,<\/span> which<\/span> is<\/span> ensured<\/span> by<\/span> careful<\/span> mixing<\/span> of<\/span> medicinal<\/span> and<\/span> auxiliary<\/span> substances<\/span> and<\/span> their<\/span> uniform<\/span> distribution<\/span> in<\/span> the<\/span> total<\/span> mass.<\/span> The<\/span> accuracy<\/span> of<\/span> dosing<\/span> also<\/span> depends<\/span> on<\/span> the<\/span> speed<\/span> and<\/span> reliability<\/span> of<\/span> filling<\/span> the<\/span> matrix<\/span> slot<\/span> of<\/span> the<\/span> tablet<\/span> machine.<\/span> If<\/span> less<\/span> material<\/span> is<\/span> poured<\/span> out<\/span> over<\/span> the<\/span> matrix<\/span> hole<\/span> during<\/span> the<\/span> short<\/span> stay<\/span> of<\/span> the<\/span> funnel<\/span> than<\/span> the<\/span> matrix<\/span> socket<\/span> can<\/span> accept,<\/span> the<\/span> mass<\/span> of<\/span> the<\/span> tablets<\/span> received<\/span> will<\/span> be<\/span> insufficient.<\/span> The<\/span> required<\/span> filling<\/span> rate<\/span> of<\/span> the<\/span> matrix<\/span> socket<\/span> depends<\/span> on<\/span> the<\/span> shape<\/span> of<\/span> the<\/span> funnel,<\/span> the<\/span> angle<\/span> of<\/span> the<\/span> slope<\/span> and<\/span> whether<\/span> the<\/span> particles<\/span> of<\/span> the<\/span> tableted<\/span> mass<\/span> have<\/span> sufficient<\/span> slip.<\/span> Often,<\/span> the<\/span> friction<\/span> forces<\/span> between<\/span> individual<\/span> particles<\/span> due<\/span> to<\/span> the<\/span> roughness<\/span> of<\/span> their<\/span> surface<\/span> are<\/span> so<\/span> great<\/span> that<\/span> the<\/span> matrix<\/span> socket<\/span> is<\/span> not<\/span> completely<\/span> filled<\/span> or<\/span> is<\/span> not<\/span> filled<\/span> at<\/span> all<\/span> due<\/span> to<\/span> the<\/span> delay<\/span> of<\/span> the<\/span> powder<\/span> in<\/span> the<\/span> funnel.<\/span>\r\n\r\n[\/vc_column_text][\/vc_column][\/vc_row]<\/span><\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][vc_column_text] The following requirements are imposed on tablets: dosing accuracy \u2014 uniformity (uniformity) of the distribution of the active substance in the tablet, the correctness of the weight of both the tablet itself and the medicinal substances included in it; mechanical strength \u2014 hardness, brittleness, fragility \u2014 characterize the quality of tablets; tablets must have…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false,"footnotes":""},"categories":[2199,2175],"tags":[2201,2202,2380,58,2381,114,43,2378,2374,2373,158,39,2200,2377,2370,2372,2379,95,2376,90,89,91,2375,2203,2371,212,210],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Autor Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/farmaceutico-equipos\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"TECNOLOG\u00cdA DE FABRICACI\u00d3N DE TABLETAS<\/a> TECNOLOG\u00cdAS DE PRODUCCI\u00d3N FARMAC\u00c9UTICA<\/a>","rttpg_excerpt":"[vc_row][vc_column][vc_column_text] The following requirements are imposed on tablets: dosing accuracy \u2014 uniformity (uniformity) of the distribution of the active substance in the tablet, the correctness of the weight of both the tablet itself and the medicinal substances included in it; mechanical strength \u2014 hardness, brittleness, fragility \u2014 characterize the quality of tablets; tablets must have...","_links":{"self":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/posts\/58954"}],"collection":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/comments?post=58954"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/posts\/58954\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/media?parent=58954"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/categories?post=58954"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/tags?post=58954"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}