{"id":58200,"date":"2024-01-16T11:17:21","date_gmt":"1970-01-01T00:00:00","guid":{"rendered":"https:\/\/minipress.ru\/katalog\/?p=58200"},"modified":"2024-01-16T11:17:21","modified_gmt":"1970-01-01T00:00:00","slug":"substances-for-film-coating-of-tablets","status":"publish","type":"post","link":"https:\/\/minipress.ru\/farmaceutico-equipos\/tecnologias-de-produccion-farmaceutica\/substances-for-film-coating-of-tablets\/","title":{"rendered":"Substances for film coating of tablets"},"content":{"rendered":"
[vc_row][vc_column][vc_column_text]<\/span>\n\nThe<\/span> main<\/span> components<\/span> in<\/span> most<\/span> finished<\/span> dosage<\/span> forms<\/span> with<\/span> a<\/span> film<\/span> coating<\/span> are<\/span> polymers,<\/span> plasticizers,<\/span> dyes<\/span> and<\/span> solvents<\/span> (or<\/span> the<\/span> liquid<\/span> phase).<\/span> Polymers.<\/span> Ideal<\/span> properties<\/span> for<\/span> the<\/span> polymer<\/span> are<\/span> solubility<\/span> in<\/span> a<\/span> wide<\/span> range<\/span> of<\/span> solvents<\/span> for<\/span> the<\/span> variation<\/span> of<\/span> the<\/span> composition<\/span> of<\/span> the<\/span> finished<\/span> dosage<\/span> form,<\/span> the<\/span> possibility<\/span> of<\/span> creating<\/span> a<\/span> coating<\/span> with<\/span> suitable<\/span> mechanical<\/span> properties,<\/span> and<\/span> the<\/span> corresponding<\/span> solubility<\/span> in<\/span> gastrointestinal<\/span> fluids<\/span> -<\/span> such<\/span> as<\/span> not<\/span> to<\/span> reduce<\/span> the<\/span> bioavailability<\/span> of<\/span> medicinal<\/span> substances.<\/span> The<\/span> most<\/span> suitable<\/span> polymers<\/span> for<\/span> film<\/span> coatings<\/span> are<\/span> cellulose<\/span> esters,<\/span> especially<\/span> hydroxypropylmethylcellulose<\/span> (HPC),<\/span> hydroxypropylcellulose<\/span> (HPC),<\/span> with<\/span> which<\/span> slightly<\/span> sticky<\/span> coatings<\/span> are<\/span> obtained,<\/span> and<\/span> methylcellulose<\/span> (MC),<\/span> although<\/span> this<\/span> polymer<\/span> can<\/span> slow<\/span> down<\/span> the<\/span> dissolution<\/span> of<\/span> the<\/span> medicinal<\/span> substance.<\/span>\nAlternatives<\/span> to<\/span> cellulose<\/span> esters<\/span> are<\/span> acrylic<\/span> copolymers<\/span> (such<\/span> as<\/span> methacrylic<\/span> and<\/span> methyl<\/span> methacrylic<\/span> copolymers)<\/span> and<\/span> vinyl<\/span> polymers<\/span> (such<\/span> as<\/span> polyvinyl<\/span> alcohol).<\/span> Polymers<\/span> can<\/span> be<\/span> used<\/span> both<\/span> individually<\/span> and<\/span> in<\/span> a<\/span> mixture<\/span> to<\/span> achieve<\/span> an<\/span> optimal<\/span> release<\/span> profile<\/span> of<\/span> the<\/span> drug<\/span> substance.<\/span>\nHowever,<\/span> when<\/span> using<\/span> polymer<\/span> mixtures,<\/span> it<\/span> is<\/span> necessary<\/span> to<\/span> determine<\/span> the<\/span> optimal<\/span> ratio<\/span> of<\/span> their<\/span> concentrations.<\/span> For<\/span> example,<\/span> a<\/span> mixture<\/span> of<\/span> water-insoluble<\/span> polymer<\/span> ethyl<\/span> cellulose<\/span> and<\/span> water-soluble<\/span> hydroxypropylmethylcellulose<\/span> can<\/span> be<\/span> used<\/span> for<\/span> controlled<\/span> release<\/span> of<\/span> a<\/span> medicinal<\/span> substance.<\/span>\n\n[\/vc_column_text][\/vc_column][\/vc_row]<\/span><\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][vc_column_text] The main components in most finished dosage forms with a film coating are polymers, plasticizers, dyes and solvents (or the liquid phase). Polymers. Ideal properties for the polymer are solubility in a wide range of solvents for the variation of the composition of the finished dosage form, the possibility of creating a coating with…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false,"footnotes":""},"categories":[2185,2175],"tags":[2380,2381,43,2378,2374,2373,75,78,2377,2370,76,77,63,2372,2379,95,2190,2189,2376,2375,2371,212,2186],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Autor Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/farmaceutico-equipos\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"RECUBRIMIENTO DE PEL\u00cdCULA DE TABLETAS<\/a> TECNOLOG\u00cdAS DE PRODUCCI\u00d3N FARMAC\u00c9UTICA<\/a>","rttpg_excerpt":"[vc_row][vc_column][vc_column_text] The main components in most finished dosage forms with a film coating are polymers, plasticizers, dyes and solvents (or the liquid phase). Polymers. Ideal properties for the polymer are solubility in a wide range of solvents for the variation of the composition of the finished dosage form, the possibility of creating a coating with...","_links":{"self":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/posts\/58200"}],"collection":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/comments?post=58200"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/posts\/58200\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/media?parent=58200"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/categories?post=58200"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/tags?post=58200"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}