{"id":58196,"date":"2024-01-16T13:21:07","date_gmt":"2024-01-16T10:21:07","guid":{"rendered":"https:\/\/minipress.ru\/katalog\/?p=58196"},"modified":"2024-04-01T12:26:05","modified_gmt":"2024-04-01T09:26:05","slug":"produccion-de-capsulas-de-gelatina-dura","status":"publish","type":"post","link":"https:\/\/minipress.ru\/farmaceutico-equipos\/tecnologias-de-produccion-farmaceutica\/produccion-de-capsulas-de-gelatina-dura\/","title":{"rendered":"Producci\u00f3n de c\u00e1psulas de gelatina dura"},"content":{"rendered":"
[vc_row][vc_column][vc_column_text]<\/span>\r\n\r\nAs<\/span> noted<\/span> above,<\/span> encapsulated<\/span> dosage<\/span> forms<\/span> are<\/span> becoming<\/span> increasingly<\/span> important<\/span> due<\/span> to<\/span> their<\/span> obvious<\/span> advantages<\/span> over<\/span> other<\/span> dosage<\/span> forms.<\/span> This<\/span> section<\/span> will<\/span> consider<\/span> the<\/span> technology<\/span> of<\/span> production<\/span> of<\/span> solid<\/span> gelatin<\/span> capsules,<\/span> which<\/span> are<\/span> most<\/span> widely<\/span> used<\/span> in<\/span> the<\/span> modern<\/span> pharmaceutical<\/span> industry,<\/span> as<\/span> well<\/span> as<\/span> the<\/span> equipment<\/span> on<\/span> which<\/span> their<\/span> manufacture<\/span> is<\/span> carried<\/span> out.<\/span> Characteristics<\/span> of<\/span> the<\/span> main<\/span> and<\/span> auxiliary<\/span> substances<\/span> included<\/span> in<\/span> the<\/span> composition<\/span> of<\/span> solid<\/span> gelatin<\/span> capsules.<\/span> To<\/span> obtain<\/span> capsule<\/span> shells,<\/span> film-forming<\/span> high-molecular<\/span> substances<\/span> capable<\/span> of<\/span> forming<\/span> elastic<\/span> films<\/span> characterized<\/span> by<\/span> a<\/span> certain<\/span> mechanical<\/span> strength<\/span> are<\/span> used.<\/span> Such<\/span> materials<\/span> include<\/span> casein,<\/span> zein,<\/span> cellulose<\/span> esters<\/span> and<\/span> esters,<\/span> fats<\/span> and<\/span> wax-like<\/span> substances,<\/span> as<\/span> well<\/span> as<\/span> some<\/span> synthetic<\/span> polymers<\/span> (for<\/span> example,<\/span> a<\/span> copolymer<\/span> of<\/span> methacrylamide<\/span> and<\/span> methacrylic<\/span> acid,<\/span> etc.).<\/span> However,<\/span> these<\/span> substances<\/span> have<\/span> not<\/span> found<\/span> wide<\/span> practical<\/span> application<\/span> for<\/span> pharmaceutical<\/span> capsules,<\/span> and<\/span> therefore,<\/span> to<\/span> date,<\/span> the<\/span> pharmaceutical<\/span> industry<\/span> produces<\/span> mainly<\/span> gelatin<\/span> capsules.<\/span>\r\n*<\/span> One<\/span> of<\/span> the<\/span> most<\/span> common<\/span> forming<\/span> materials<\/span> for<\/span> the<\/span> production<\/span> of<\/span> gelatin<\/span> capsules<\/span> is<\/span> gelatin,<\/span> a<\/span> high\u2014molecular<\/span> compound<\/span> of<\/span> a<\/span> protein<\/span> nature.<\/span>\r\nIt<\/span> is<\/span> a<\/span> product<\/span> of<\/span> partial<\/span> hydrolysis<\/span> of<\/span> collagen,<\/span> which<\/span> forms<\/span> the<\/span> main<\/span> part<\/span> of<\/span> the<\/span> connective<\/span> tissue<\/span> of<\/span> vertebrates<\/span> (bones,<\/span> cartilage,<\/span> horns,<\/span> hooves,<\/span> skin,<\/span> tendons<\/span> of<\/span> cattle<\/span> and<\/span> pig<\/span> skin).<\/span> The<\/span> protein<\/span> molecule<\/span> of<\/span> gelatin<\/span> is<\/span> based<\/span> on<\/span> a<\/span> polypeptide<\/span> chain<\/span> formed<\/span> by<\/span> 19<\/span> amino<\/span> acids,<\/span> most<\/span> of<\/span> which<\/span> are<\/span> indispensable<\/span> for<\/span> the<\/span> human<\/span> body.<\/span> The<\/span> main<\/span> ones<\/span> are:<\/span> glycine<\/span> (up<\/span> to<\/span> 30%),<\/span> proline,<\/span> oxyproline,<\/span> glutamic<\/span> acid,<\/span> arginine<\/span> and<\/span> lysine.<\/span>\r\nCollagen<\/span> of<\/span> bones<\/span> and<\/span> animal<\/span> skins<\/span> is<\/span> macerated<\/span> (softened<\/span> and<\/span> loosened<\/span> due<\/span> to<\/span> prolonged<\/span> exposure<\/span> to<\/span> liquids)<\/span> and<\/span> purified<\/span> with<\/span> acids<\/span> or<\/span> alkalis,<\/span> which<\/span> split<\/span> it<\/span> hydrolytically<\/span> into<\/span> practically<\/span> unbranched<\/span> amino<\/span> acid<\/span> chains<\/span> of<\/span> various<\/span> lengths,<\/span> i.e.<\/span> gelatin.<\/span> Depending<\/span> on<\/span> the<\/span> chain<\/span> length,<\/span> gelatin<\/span> has<\/span> a<\/span> molecular<\/span> weight<\/span> from<\/span> 40<\/span> OOO<\/span> to<\/span> 100<\/span> OOO,<\/span> the<\/span> decomposition<\/span> method<\/span> used<\/span> determines<\/span> the<\/span> nature<\/span> of<\/span> the<\/span> final<\/span> product.<\/span>\r\n\r\n[\/vc_column_text][\/vc_column][\/vc_row]<\/span><\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][vc_column_text] As noted above, encapsulated dosage forms are becoming increasingly important due to their obvious advantages over other dosage forms. This section will consider the technology of production of solid gelatin capsules, which are most widely used in the modern pharmaceutical industry, as well as the equipment on which their manufacture is carried out. Characteristics…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false,"footnotes":""},"categories":[2177,2175],"tags":[2380,2381,88,83,81,82,2378,2374,2373,85,84,39,141,2377,2370,2372,2379,2376,142,2375,143,2371],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Autor Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/farmaceutico-equipos\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"PRODUCCI\u00d3N DE C\u00c1PSULAS DE GELATINA PARA MEDICAMENTOS.<\/a> TECNOLOG\u00cdAS DE PRODUCCI\u00d3N FARMAC\u00c9UTICA<\/a>","rttpg_excerpt":"[vc_row][vc_column][vc_column_text] As noted above, encapsulated dosage forms are becoming increasingly important due to their obvious advantages over other dosage forms. This section will consider the technology of production of solid gelatin capsules, which are most widely used in the modern pharmaceutical industry, as well as the equipment on which their manufacture is carried out. Characteristics...","_links":{"self":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/posts\/58196"}],"collection":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/comments?post=58196"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/posts\/58196\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/media?parent=58196"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/categories?post=58196"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/tags?post=58196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}