{"id":58068,"date":"2024-01-16T15:23:28","date_gmt":"1970-01-01T00:00:00","guid":{"rendered":"https:\/\/minipress.ru\/katalog\/?p=58068"},"modified":"2024-02-22T11:15:47","modified_gmt":"2024-02-22T08:15:47","slug":"tecnologias-de-llenado-para-capsulas-de-gelatina-dura","status":"publish","type":"post","link":"https:\/\/minipress.ru\/farmaceutico-equipos\/tecnologias-de-produccion-farmaceutica\/tecnologias-de-llenado-para-capsulas-de-gelatina-dura\/","title":{"rendered":"Tecnolog\u00edas de llenado para c\u00e1psulas de gelatina dura"},"content":{"rendered":"
Over<\/span> the<\/span> past<\/span> few<\/span> years,<\/span> capsule<\/span> filling<\/span> technology<\/span> has<\/span> undergone<\/span> significant<\/span> changes<\/span> in<\/span> the<\/span> pharmaceutical<\/span> industry.<\/span> The<\/span> basic<\/span> idea<\/span> of<\/span> capsule<\/span> filling<\/span> has<\/span> expanded<\/span> from<\/span> filling<\/span> with<\/span> solid<\/span> forms<\/span> to<\/span> filling<\/span> with<\/span> liquid<\/span> forms.<\/span> Until<\/span> recently,<\/span> soft<\/span> gelatin<\/span> capsules<\/span> were<\/span> the<\/span> only<\/span> alternative<\/span> for<\/span> encapsulating<\/span> difficult-to-dissolve<\/span> dosage<\/span> forms.<\/span> Today,<\/span> new<\/span> technologies<\/span> have<\/span> been<\/span> developed<\/span> for<\/span> filling<\/span> solid<\/span> gelatin<\/span> capsules<\/span> with<\/span> liquid<\/span> medicinal<\/span> substances<\/span> and<\/span> sealing<\/span> them<\/span> as<\/span> an<\/span> alternative<\/span> replacement<\/span> for<\/span> soft<\/span> gelatin<\/span> capsules.<\/span> This<\/span> simplifies<\/span> the<\/span> process<\/span> of<\/span> filling<\/span> capsules<\/span> and<\/span> helps<\/span> to<\/span> avoid<\/span> many<\/span> problems<\/span> associated<\/span> with<\/span> filling<\/span> soft<\/span> gelatin<\/span> capsules.<\/span> The<\/span> fundamental<\/span> differences<\/span> between<\/span> the<\/span> filling<\/span> of<\/span> hard<\/span> and<\/span> soft<\/span> gelatin<\/span> capsules<\/span> are<\/span> as<\/span> follows.<\/span> Moisture<\/span> content.<\/span> In<\/span> solid<\/span> gelatin<\/span> capsules,<\/span> the<\/span> moisture<\/span> content<\/span> can<\/span> reach<\/span> up<\/span> to<\/span> 50%.<\/span> Soft<\/span> gelatin<\/span> capsules<\/span> consist<\/span> of<\/span> a<\/span> plasticizer<\/span> that<\/span> retains<\/span> up<\/span> to<\/span> 30%<\/span> moisture.<\/span> As<\/span> a<\/span> result,<\/span> the<\/span> moisture<\/span> absorption<\/span> capacity<\/span> of<\/span> soft<\/span> gelatin<\/span> capsules<\/span> is<\/span> much<\/span> higher<\/span> than<\/span> that<\/span> of<\/span> solid<\/span> ones.<\/span> Another<\/span> property<\/span> of<\/span> the<\/span> plasticizer<\/span> is<\/span> the<\/span> migration<\/span> of<\/span> the<\/span> filler<\/span> into<\/span> the<\/span> walls<\/span> of<\/span> a<\/span> soft<\/span> gelatin<\/span> capsule,<\/span> which<\/span> can<\/span> lead<\/span> to<\/span> a<\/span> change<\/span> in<\/span> the<\/span> formula<\/span> of<\/span> the<\/span> medicinal<\/span> substance.<\/span> Oxygen<\/span> transmission<\/span> level.<\/span> In<\/span> the<\/span> film<\/span> of<\/span> soft<\/span> gelatin<\/span> capsules,<\/span> the<\/span> level<\/span> of<\/span> oxygen<\/span> transfer<\/span> increases<\/span> with<\/span> an<\/span> increase<\/span> in<\/span> the<\/span> level<\/span> of<\/span> glycerin<\/span> and<\/span> moisture.<\/span> Since<\/span> the<\/span> content<\/span> of<\/span> plasticizer<\/span> in<\/span> hard<\/span> gelatin<\/span> capsules<\/span> is<\/span> minimal,<\/span> the<\/span> permeability<\/span> of<\/span> their<\/span> walls<\/span> is<\/span> lower<\/span> than<\/span> that<\/span> of<\/span> soft<\/span> gelatin<\/span> capsules.<\/span> As<\/span> a<\/span> result,<\/span> solid<\/span> gelatin<\/span> capsules<\/span> can<\/span> be<\/span> filled<\/span> with<\/span> medicinal<\/span> substances<\/span> with<\/span> high<\/span> odor<\/span> permeability,<\/span> such<\/span> as<\/span> fish<\/span> oil,<\/span> valerian<\/span> and<\/span> garlic<\/span> oil.<\/span> In<\/span> addition,<\/span> the<\/span> aesthetic<\/span> appearance<\/span> of<\/span> the<\/span> dosage<\/span> form<\/span> worries<\/span> many<\/span> manufacturers.<\/span> This<\/span> problem<\/span> is<\/span> easier<\/span> to<\/span> solve<\/span> when<\/span> filling<\/span> solid<\/span> gelatin<\/span> capsules<\/span> with<\/span> liquids<\/span> and<\/span> sealing<\/span> them,<\/span> since<\/span> there<\/span> is<\/span> a<\/span> whole<\/span> color<\/span> scheme<\/span> to<\/span> improve<\/span> their<\/span> appearance.<\/span> Biological<\/span> activity.<\/span> The<\/span> biological<\/span> activity<\/span> of<\/span> difficult-to-dissolve<\/span> medicinal<\/span> substances<\/span> can<\/span> significantly<\/span> increase<\/span> if<\/span> these<\/span> substances<\/span> are<\/span> \"packaged\"<\/span> in<\/span> solid<\/span> gelatin<\/span> capsules,<\/span> which<\/span> makes<\/span> their<\/span> use<\/span> possible<\/span> and<\/span> increases<\/span> the<\/span> effectiveness<\/span> of<\/span> the<\/span> drug.<\/span> The<\/span> dissolution<\/span> temperature.<\/span> Materials<\/span> with<\/span> a<\/span> low<\/span> dissolution<\/span> temperature<\/span> (or<\/span> those<\/span> materials<\/span> that<\/span> become<\/span> liquid<\/span> at<\/span> room<\/span> temperature)<\/span> are<\/span> difficult<\/span> to<\/span> produce<\/span> in<\/span> powder<\/span> form.<\/span><\/span><\/pre>\n","protected":false},"excerpt":{"rendered":"
Over the past few years, capsule filling technology has undergone significant changes in the pharmaceutical industry. The basic idea of capsule filling has expanded from filling with solid forms to filling with liquid forms. Until recently, soft gelatin capsules were the only alternative for encapsulating difficult-to-dissolve dosage forms. Today, new technologies have been developed for…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"gallery","meta":{"inline_featured_image":false,"footnotes":""},"categories":[2177,2175],"tags":[2380,2381,83,81,82,2378,2374,2373,85,84,39,141,2377,2370,2372,2379,2376,142,2375,2371],"rttpg_featured_image_url":null,"rttpg_author":{"display_name":".. Autor Roman Tsibulsky","author_link":"https:\/\/minipress.ru\/farmaceutico-equipos\/author\/admin\/"},"rttpg_comment":0,"rttpg_category":"PRODUCCI\u00d3N DE C\u00c1PSULAS DE GELATINA PARA MEDICAMENTOS.<\/a> TECNOLOG\u00cdAS DE PRODUCCI\u00d3N FARMAC\u00c9UTICA<\/a>","rttpg_excerpt":"Over the past few years, capsule filling technology has undergone significant changes in the pharmaceutical industry. The basic idea of capsule filling has expanded from filling with solid forms to filling with liquid forms. Until recently, soft gelatin capsules were the only alternative for encapsulating difficult-to-dissolve dosage forms. Today, new technologies have been developed for...","_links":{"self":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/posts\/58068"}],"collection":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/comments?post=58068"}],"version-history":[{"count":0,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/posts\/58068\/revisions"}],"wp:attachment":[{"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/media?parent=58068"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/categories?post=58068"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/minipress.ru\/farmaceutico-equipos\/wp-json\/wp\/v2\/tags?post=58068"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}