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TECNOLOGÍA DE FORMAS FARMACÉUTICAS BLANDAS

Tecnologías y equipos para la producción de formas farmacéuticas blandas.

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  • Tecnologías y equipos para la producción de formas farmacéuticas blandas.
  • Equipment for the production of ointments
  • Equipment for the production of body cream
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The process of making ointments can be periodic or continuous. The periodic process can be one-, two-, three-stage, etc., depending on the number of devices in which separate stages of the process of obtaining ointments are consistently carried out. The technology of manufacturing ointments at pharmaceutical enterprises is carried out in accordance with the regulations. It includes the following stages: sanitary treatment of premises and equipment; preparation of raw materials (medicinal substances, ointment base, packaging containers, etc.); introduction of medicinal substances into the base; homogenization of ointments; standardization; packing and storage of ointments. Sanitary treatment of premises and equipment is aimed at preventing microbial contamination during the production, storage and transportation of ointments, at creating safe working conditions and protecting the health of workers.

Requisitos básicos de las formas farmacéuticas blandas gmp

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  • Requisitos básicos de las formas farmacéuticas blandas gmp
  • Equipos de producción de cremas y ungüentos.
  • Standardization of ointments in production
  • Emulsifiers in the production of ointments
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In the production of ointments, creams and other soft dosage forms, there is a particularly high risk of microbial and other contamination. Therefore, special measures are needed to prevent any contamination. Soft dosage forms have specific rheological properties and in most cases are heterogeneous dispersed systems. Therefore, in order to avoid heterogeneity of the product due to uneven distribution of components, formation of gas emulsions and destabilization of dispersed systems, special attention should be paid to the proper conduct of the technological process, the equipment used and the temperature conditions of product storage. Requirements for production facilities and equipment. The environment of the premises, taking into account all measures to protect production, should pose a minimal risk in terms of contamination of materials and products.

Clasificación de formas farmacéuticas blandas

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  • producción de cremas
  • Production of ointments
  • Clasificación de formas farmacéuticas blandas.
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Based on the above, the following classification of soft dosage forms is proposed: 1. Ointments by base type are divided into three groups: hydrophobic (lipophilic), hydrophobic absorption (emulsion) and hydrophilic ointments. Hydrophobic (lipophilic) ointments are prepared mainly on hydrocarbon bases (petroleum jelly, petroleum jelly oil, paraffin) and may contain other lipophilic excipients (vegetable oils, animal fats, waxes, synthetic glycerides and liquid polyalkyl-loxans). Only small amounts of water or aqueous solutions can be introduced into their composition. Hydrophobic ointments when used have an occlusive (preventing contact with air) effect, have a softening effect, are difficult to wash off with water and do not mix with exudate. Hydrophobic absorption ointments. Absorption ointments are hydrophobic, however, when rubbed into the skin, they can absorb (emulsify) exudate. The bases...
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